Blood gas profile of copper-poisoned in sheep treated with ammonium tetrathiomolybdate

Autores

  • Pierre Castro Soares Universidade Federal Rural de Pernambuco
  • Marta Lizandra do Rêgo Leal Universidade Federal de Santa Maria
  • Clara Satisuki Mori Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo
  • Maria Claudia Araripe Sucupira Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo
  • Enrico Lippi Ortolani Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo

DOI:

https://doi.org/10.5433/1679-0359.2012v33n2p731

Palavras-chave:

Sheep, Blood gas, Cooper, Ammonium tetrathiomolybdate.

Resumo

The aim of this study was to evaluate the blood gas profile of experimentally copper-poisoned sheep (in the pre-hemolytic, hemolytic and post-hemolytic phases) that have been treated or not treated with ammonium tetrathiomolybdate. Ten lambs of the Santa Ines breed were divided into two groups: control and ATTM (treated (ammonium tetrathiomolibydate). The animals were submitted to increasing doses of copper sulfate until macroscopic hemoglobinuria was detected.All of the control animals from died within four days of hemolytic crisis, and one sheep from ATTM died during the treatment. There was no difference in blood gas parameters between experimental groups. Higher values of pCO2 were observed during the hemolytic crisis (HC) in both groups. The control group had higher mean values of hCO3 in the times HC and 2 days after hemolytic crisis (dA) when compared with the time 15 before hemolytic crises (dB). The sheep that were treated with ATTM presented lower values of hCO3 at 7dB and higher levels at the HC. The control and ATTM groups exhibited higher values of BE during the HC. Poisoning resulted in disorder in the acid-base equilibrium, characterized by metabolic alkalosis and respiratory acidosis. Treatment with ATTM was able to reverse the changes in acid-base balance in copper poisoning sheep.

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Biografia do Autor

Pierre Castro Soares, Universidade Federal Rural de Pernambuco

Prof. Dr. Universidade Federal Rural de Pernambuco, UFRPE, Pernambuco, PE.

Marta Lizandra do Rêgo Leal, Universidade Federal de Santa Maria

Profa. Dra. Universidade Federal de Santa Maria, UFSM, Santa Maria, RS.

Clara Satisuki Mori, Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo

Química, Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo, FMVZ-USP, São Paulo, SP.

Maria Claudia Araripe Sucupira, Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo

Profa. Dra. da FMVZ-USP, São Paulo, SP.

Enrico Lippi Ortolani, Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo

Prof. Titular da FMVZ-USP, São Paulo, SP.

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Publicado

2012-05-14

Como Citar

Soares, P. C., Leal, M. L. do R., Mori, C. S., Sucupira, M. C. A., & Ortolani, E. L. (2012). Blood gas profile of copper-poisoned in sheep treated with ammonium tetrathiomolybdate. Semina: Ciências Agrárias, 33(2), 731–740. https://doi.org/10.5433/1679-0359.2012v33n2p731

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