High doses of lidocaine as a constant rate infusion in propofol/fentanyl anaesthetized sheep: cardiorespiratory effects

Autores

  • Ewaldo de Mattos-Junior Universidade de Franca
  • Antonio Humberto Hamad Minervino Universidade Federal do Oeste do Pará
  • Raimundo Alves Barrêto-Júnior Universidade Federal do Semi-Árido
  • Frederico Augusto Mazzocca Lopes Rodrigues Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo
  • Carolina Akiko Sato Cabral Araújo Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo
  • Enrico Lippi Ortolani Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo
  • Silvia Renata Gaido Cortopassi Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo

DOI:

https://doi.org/10.5433/1679-0359.2013v34n1p323

Palavras-chave:

Sheep, Local anesthetic, Injectable anesthetic, Opioids.

Resumo

The aim of this study was to investigate the cardiorespiratory and anesthetic-sparing effects of a highdose CRI of lidocaine (200 ?g/kg/min) administered with a propofol/fentanyl regimen to sheep. Twelve adult, castrated male sheep (BW= 32.1 ± 4.9 kg), were used in a prospective, randomized clinical trial. All animals were premedicated with xylazine (0.05 mg/kg, i.m.). Animals in the GPF group were induced with propofol (3 mg/kg) and fentanyl (2.5 ?g/kg) intravenously, and anesthesia was maintained with a CRI of propofol (500 ?g/kg/min) and fentanyl (0.15 ?g/kg/min). In the GPFL group, animals were induced with propofol (3 mg/kg), fentanyl (2.5 ?g/kg) and lidocaine (2.5 mg/kg) intravenously, and anesthesia was maintained with a CRI of propofol (500 ?g/kg/min), fentanyl (0.15 ?g/kg/min) and lidocaine (200 ?g/kg/min); after ten minutes of anesthesia, the propofol dose was reduced by 25% (from 500 ?g/kg/min to 375 ?g/kg/min). Cardiorespiratory parameters were recorded from 15 minutes after preanesthetic medication administration (T0) to the end of the anesthetic procedure (T7). The time points were as follows: T0 – 15 minutes after preanesthetic medication administration; T1 – after anesthesia induction and orotracheal intubation; T2 – 15 minutes of anesthesia; T3 – during traction on the liver; T4 – during bowel clamping; T5 – during muscle suture; T6 – at the end of skin suture; and T7 – 15 minutes after the end of anesthesia. Apnea was present in all animals during anesthesia induction and required mechanical ventilation. There was no statistical difference in HR and MAP between any time points compared to the baseline value (p > 0.05); MAP was lower in the GPF group (p < 0.05) at time T6. In conclusion, this dose of lidocaine was sufficient to reduce the propofol requirement by 25%. A high-dose CRI of lidocaine in combination with a propofol/fentanyl regmine did not promote significant cardiovascular changes and was effective in reducing the propofol dose by 25%.

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Biografia do Autor

Ewaldo de Mattos-Junior, Universidade de Franca

Prof. Dr. de Anestesiologia e Farmacologia Veterinária, Universidade de Franca, Franca, SP.

Antonio Humberto Hamad Minervino, Universidade Federal do Oeste do Pará

Prof. Dr. Instituto de Biodiversidade e Floresta, Universidade Federal do Oeste do Pará, Santarém, PA.

Raimundo Alves Barrêto-Júnior, Universidade Federal do Semi-Árido

Prof. Dr. de Clínica Médica de Ruminantes, Universidade Federal do Semi-Árido, Mossoró, RN.

Frederico Augusto Mazzocca Lopes Rodrigues, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo

Discente do Programa de Pós-Graduação em Clínica Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, FMVZ/USP, São Paulo, SP.

Carolina Akiko Sato Cabral Araújo, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo

Discente do Programa de Pós-Graduação em Clínica Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, FMVZ/USP, São Paulo, SP.

Enrico Lippi Ortolani, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo

Prof. Titular do Deptº de Clínica Médica, F FMVZ/USP, São Paulo, SP.

Silvia Renata Gaido Cortopassi, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo

Profª. Livre-docente do Deptº de Cirurgia, FMVZ/USP, São Paulo, SP.

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Publicado

2013-03-04

Como Citar

Mattos-Junior, E. de, Minervino, A. H. H., Barrêto-Júnior, R. A., Rodrigues, F. A. M. L., Araújo, C. A. S. C., Ortolani, E. L., & Cortopassi, S. R. G. (2013). High doses of lidocaine as a constant rate infusion in propofol/fentanyl anaesthetized sheep: cardiorespiratory effects. Semina: Ciências Agrárias, 34(1), 323–334. https://doi.org/10.5433/1679-0359.2013v34n1p323

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