Efeitos cardiorrespiratórios e hemogasométricos da cetamina e suas associações com morfina e xilazina por via epidural em ovinos
DOI:
https://doi.org/10.5433/1679-0359.2021v42n1p241Palavras-chave:
Analgesia, Anestesia loco-regional, Equilíbrio ácido-base.Resumo
This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best option for short procedures as obstetric manipulations in sheep due to its cardiorespiratory stability when compared with the protocols using associations.
Métricas
Referências
DeRossi, R., Módolo, T. J. C., Pagliosa, R. C., Jardim, P. H. A., Maciel, F. B., & Macedo, G. G. (2012). Comparison of analgesic effects of caudal epidural 0.25% bupivacaine with bupivacaine plus morphine or bupivacaine plus ketamine for analgesia in conscious horses. Journal of Equine Veterinary Science, 32, 190-195. doi: 10.1111/j.1467-2995.2011.00689.x
Freitas, G. C., Carregaro, A. B., Gehrcke, M. I., De La Côrte, F. D., Lara, V., Pozzobon, R., & Brass, K. E. (2011). Epidural analgesia with morphine or buprenorphine in ponies with lipopolysaccharide (LPS)-induced carpal synovitis. Canadian Journal of Veterinary Research, 75(2), 141-146. doi: 10.15361/ 2175-0106.2008v24n2p103-109
Guirro, E. C. B. P., Sobrinho, G. R., Ferreira, I. M. M., & Valadão, C. A. A. (2011). Efeitos comportamental, clínico e analgésico promovidos pela injeção epidural preventiva de morfina, xilazina ou clonidina, em equinos. Ciência Rural, 41(10), 1790-1796. doi: 10.1590/S0103-84782011001000019
Habibian, S., Bigham, A. S., & Aali, E. (2011). Comparison of lidocaine, tramadol, and lidocaine-tramadol for epidural analgesia in lambs. Research in Veterinary Science, 91(3), 434-438. doi: 10.1016/j.rvsc. 2010.09.023
Ismail, Z. B. (2016). Epidural analgesia in sheep and goats: a review of recent literature. Bulletin UASVM Veterinary Medicine, 73(2), 197-202. doi: 10.15835/buasvmcn-vm:12078
Ismail, Z. B., Jawasreh, K., & Al-Majali, A. (2010). Effect of xylazine-ketamine-diazepam anesthesia on certain clinical and arterial blood gas parameters in sheep and goats. Comparative Clinical Pathology, 19(1), 11-14. doi: 10.1007/s00580-009-0896-6
Kastner, S. B. R. (2006). Alpha2-agonists in sheep: a review. Veterinary Anaesthesia and Analgesia, 33, 79-96. doi: 10.1111/j.1467-2995.2005.00243.x
Monteiro, E. R., Rodrigues, A. Jr., Assis, H. M. Q., Campagnol, D., Quitzan, J. G. (2009). Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs. Veterunary Anaesthesia and Analgesia, 36, 25-33. doi:10.1111/j.1467-2995. 2008.00424.x
Moraes, V. J., Madureira, K. M., Bittencourt, R. F., Iwassa, C. H. D., & Barbosa, V. F. (2018). Postoperative pain management in a sheep using continuous epidural morphine. Acta Scientiae Veterinariae, 46(1), 254. doi: 10.22456/1679-9216.85150
Munksgaard, L., Depassillé, A. M., Rushen, J., Herskin, M. S., & Kristensen, A. M. (2001). Dairy cows’ fear of people: social learning, milk yield and behaviour at milking. Applied Animal Behaviour Science, 73(1), 15-26. doi: 10.1016/S0168-1591(01)00119-8
Rostami, M., & Vesal, N. (2012). The effects of adding epinephrine or xylazine to lidocaine solution for lumbosacral epidural analgesia in fat-tailed sheep. Journal of South African Veterinary Association, 83(1), 1-7. doi: 10.4102/ jsava.v83i1.1
Shah, Z., Ding, M.-X., Hu, M.-L. (2014). Alfa2 antagonist in ruminant. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 20(4), 633-639. doi: 10.9775/kvfd.2013.10541
Singh, P. M., Reid, K., Gaddam, R., Bhatia, M., Smith, S., Jacob, A., & Chambers, P. (2017). Effect of choline chloride premedication on xylazine-induced hypoxaemia in sheep. Veterinary Anaesthesia and Analgesia, 44(5), 1149-1155. doi: 10.1016/j.vaa.2017.01.002
Soares, P. C., Leal, M. L. R., Mori, C. S., Sucupira, M. C. A., & Ortolani, E. L. (2012). Blood gas profile of copper-poisoned in sheep treated with ammonium tetrathiomolybdate. Semina: Ciência Agrárias, 33(2), 731-740. doi: 10.5433/1679-0359.2012v33n2p731
Statistical Analysis System Institute Inc., 2013, Cary, NC, USA.
Wilson, D. V., Evans, A. T., Carpenter, R. E., & Mullineaux, D. R. (2004). The effect of four anesthetic protocols on splenic size in dogs. Veterinary Anaesthesia and Analgesia, 31(2), 102-108. doi: 10.1111/ j.1467-2987.2004.00152.x
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2020 Semina: Ciências Agrárias
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.
Os Direitos Autorais para artigos publicados são de direito da revista. Em virtude da aparecerem nesta revista de acesso público, os artigos são de uso gratuito, com atribuições próprias, em aplicações educacionais e não-comerciais.
A revista se reserva o direito de efetuar, nos originais, alterações de ordem normativa, ortográfica e gramatical, com vistas a manter o padrão culto da língua e a credibilidade do veículo. Respeitará, no entanto, o estilo de escrever dos autores.
Alterações, correções ou sugestões de ordem conceitual serão encaminhadas aos autores, quando necessário. Nesses casos, os artigos, depois de adequados, deverão ser submetidos a nova apreciação.
As opiniões emitidas pelos autores dos artigos são de sua exclusiva responsabilidade.
