Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep

Authors

DOI:

https://doi.org/10.5433/1679-0359.2021v42n1p241

Keywords:

Analgesia, Loco-regional anesthesia, Acid-base balance.

Abstract

This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best option for short procedures as obstetric manipulations in sheep due to its cardiorespiratory stability when compared with the protocols using associations.

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Author Biographies

Ceci Ribeiro Leite, Universidade Federal Fluminense

Dra, MV. Servidora, Universidade Federal Fluminense, UFF, Niterói, RJ, Brasil.

Fabio Otero Ascoli, Universidade Federal Fluminense

Prof. Dr., Curso de Graduação em Medicina Veterinária, UFF, Niterói, RJ, Brasil.

Juliana de Oliveira, Universidade Federal Fluminense

Profa Dra, Curso de Graduação em Medicina Veterinária, UFF, Niterói, RJ, Brasil.

Daniel Andrews de Moura Fernandes, Universidade Federal Fluminense

Discente do Curso de Mestrado do Programa de Pós-Graduação em Medicina Veterinária, Clínica e Reprodução Animal, UFF, Niterói, RJ, Brasil.

Jeferson Ferreira da Fonseca, Empresa Brasileira de Pesquisa Agropecuária

Dr. Pesquisador, Empresa Brasileira de Pesquisa Agropecuária, EMBRAPA, Coronel Pacheco, MG, Brasil.

Felipe Zandonadi Brandão, Universidade Federal Fluminense

Prof. Dr., Curso de Graduação em Medicina Veterinária, UFF, Niterói, RJ, Brasil.

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Published

2021-01-19

How to Cite

Leite, C. R., Ascoli, F. O., Oliveira, J. de, Fernandes, D. A. de M., Fonseca, J. F. da, & Brandão, F. Z. (2021). Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep. Semina: Ciências Agrárias, 42(1), 241–254. https://doi.org/10.5433/1679-0359.2021v42n1p241

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