Experimental infection of BALB/c mice with felid alphaherpesvirus 1
DOI:
https://doi.org/10.5433/1679-0359.2022v43n1p51Palabras clave:
Animal model, Cats, Experimental infection, FHV-1, qPCR.Resumen
Felid alphaherpesvirus type 1 (FHV-1) is an important cause of respiratory and ocular diseases in cats worldwide. Mice have been widely used to study the pathogenesis of several human and animal viruses, especially herpesviruses. This study aimed to verify whether BALB/c mice are susceptible to FHV-1 infection. The animals were intranasally inoculated with FHV-1 and their clinical signs were observed from 3 days post-infection (dpi). At 10 dpi, the animals were euthanized and the lungs, liver, spleen, and kidneys were collected for histopathological examination and quantitative polymerase chain reaction. The results showed that mice were infected with FHV-1 and reproduced several features of the disease observed in its natural host. Histological lesions and viral DNA were found in all sampled tissues, with a higher frequency of FHV-1 DNA copies detected in the lungs. All mice were seroconverted to FHV-1 at 7 dpi. To our knowledge, this is the first report of experimental infection of BALB/c mice with FHV-1. Our findings demonstrate that this murine model can contribute to our understanding of FHV-1 pathogenesis and may be useful for trials against this virus.Citas
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Maes, R. (2012). Felid herpesvirus type 1 infection in cats: a natural host model for alphaherpesvirus pathogenesis. ISRN Veterinary Science, 2012, 1-14. doi: 10.5402/2012/495830
Mahiet, C., Ergani, A., Huot, N., Alende, N., Azough, A., Salvaire, F.,… Borradeau, S. (2012). Structural variability of the herpes simplex virus 1 genome in vitro and in vivo. Journal of Virology, 86(16), 8592-8601. doi: 10.1128/JVI.00223-12
McGregor, A., Choi, K. Y., Schachtele, S. J., & Lokensgard, J. R. (2013). Human herpesviruses and animal models. In P. Michael Conn (Ed.). Animal models for the study of human diseases (pp. 905-925). San Diego, CA: Elsevier.
McGregor, G. F., Sheehan, K., & Simko, E. (2016). Pneumonia and gastritis in a cat caused by feline herpesvirus-1. Canadian Veterinary Journal, 57(2), 147-150. PMID: 26834264
Mesquita, L. P., Costa, R. C., Fusuma, M. M., Bruhn, F. R. P., Mori, E., Pituco, E. M.,… Maiorka, P. C. (2017). Susceptibility of mice to bovine herpesvirus type 5 infection in the central nervous system. Veterinary Research Communications, 41(4), 279-288. doi: 10.1007/s11259-017-9699-4
Mori, C. M. C., Mori, E., Favaro, L. L., Santos, C. R., Lara, M. C. C. S. H., Villalobos, E. M. C.,… Maiorka, P. C. (2012). Equid herpesvirus type-1 exhibits neurotropism and neurovirulence in a mouse model. Journal of Comparative Pathology, 146(2-3), 202-210. doi: 10.1016/j.jcpa.2011.04.003
Ramakrishnan, M. A. (2016). Determination of 50% endpoint titer using a simple formula. World Journal of Virology, 5, 85-86. doi: 10.5501/wjv.v5.i2.85
Rodriguez, M., Köhler, K., & Kipar A. (2018). Calicivirus co-infections in herpesvirus pneumonia in kittens. The Veterinary Journal, 236, 1-3. doi: 10.1016/j.tvjl.2018.04.004
Silva, D. S., Castro, C. C., Silva, F. S., Fernandes, M. H. V., Lorenzini, F., Cordeiro, J. M. C.,... Hübner, S. O. (2014). Perspectivas terapêuticas no tratamento das infecções pelo herpesvírus tipo 1. Revista Clínica Veterinária, 19(109), 36-44.
Thomasy, S. M., & Maggs, D. J. (2016). A review of antiviral drugs and other compounds with activity against feline herpesvirus type 1. Veterinary Ophthalmology, 19(1), 119-130. doi: 10.1111/vop.12375
Gaskell, R. M., Dennis, P. E., Goddard, L. E., Cocker, F. M., & Wills J. M. (1985). Isolation of felid herpesvirus I from the trigeminal ganglia of latently infected cats. Journal of General Virology, 66(2), 391-394. doi: 10.1099/0022-1317-66-2-391
International Committee on Taxonomy of Viruses (2020). Virus Taxonomy. London: Microbiology Society. Retrieved from https://talk.ictvonline.org/taxonomy/
Kollias, C. M., Huneke, R. B., Wigdahl, B., & Jennings, S. R. (2015). Animal models of herpes simplex virus immunity and pathogenesis. Journal of Neurovirology, 21(1), 8-23. doi: 10.1007/s13365-014-0302-2
Lefever, S., Hellemans, J., Pattyn, F., Przybylski, D. R., Taylor, C., Geurts, R.,… Vandesompele, J. (2009). RDML: structured language and reporting guidelines for real-time quantitative PCR data. Nucleic Acids Research, 37(7), 2065-2069. doi: 10.1093/nar/gkp056
Lewin, A. C., Kolb, A. W., McLellan, G. J., Bentley, E., Bernard, K. A., Newbury, S. P., & Brandt, C. R. (2018). Genomic, recombinational and phylogenetic characterization of global feline herpesvirus 1 isolates. Virology, 518(14), 385-397. doi: 10.1016/j.virol.2018.03.018
Maes, R. (2012). Felid herpesvirus type 1 infection in cats: a natural host model for alphaherpesvirus pathogenesis. ISRN Veterinary Science, 2012, 1-14. doi: 10.5402/2012/495830
Mahiet, C., Ergani, A., Huot, N., Alende, N., Azough, A., Salvaire, F.,… Borradeau, S. (2012). Structural variability of the herpes simplex virus 1 genome in vitro and in vivo. Journal of Virology, 86(16), 8592-8601. doi: 10.1128/JVI.00223-12
McGregor, A., Choi, K. Y., Schachtele, S. J., & Lokensgard, J. R. (2013). Human herpesviruses and animal models. In P. Michael Conn (Ed.). Animal models for the study of human diseases (pp. 905-925). San Diego, CA: Elsevier.
McGregor, G. F., Sheehan, K., & Simko, E. (2016). Pneumonia and gastritis in a cat caused by feline herpesvirus-1. Canadian Veterinary Journal, 57(2), 147-150. PMID: 26834264
Mesquita, L. P., Costa, R. C., Fusuma, M. M., Bruhn, F. R. P., Mori, E., Pituco, E. M.,… Maiorka, P. C. (2017). Susceptibility of mice to bovine herpesvirus type 5 infection in the central nervous system. Veterinary Research Communications, 41(4), 279-288. doi: 10.1007/s11259-017-9699-4
Mori, C. M. C., Mori, E., Favaro, L. L., Santos, C. R., Lara, M. C. C. S. H., Villalobos, E. M. C.,… Maiorka, P. C. (2012). Equid herpesvirus type-1 exhibits neurotropism and neurovirulence in a mouse model. Journal of Comparative Pathology, 146(2-3), 202-210. doi: 10.1016/j.jcpa.2011.04.003
Ramakrishnan, M. A. (2016). Determination of 50% endpoint titer using a simple formula. World Journal of Virology, 5, 85-86. doi: 10.5501/wjv.v5.i2.85
Rodriguez, M., Köhler, K., & Kipar A. (2018). Calicivirus co-infections in herpesvirus pneumonia in kittens. The Veterinary Journal, 236, 1-3. doi: 10.1016/j.tvjl.2018.04.004
Silva, D. S., Castro, C. C., Silva, F. S., Fernandes, M. H. V., Lorenzini, F., Cordeiro, J. M. C.,... Hübner, S. O. (2014). Perspectivas terapêuticas no tratamento das infecções pelo herpesvírus tipo 1. Revista Clínica Veterinária, 19(109), 36-44.
Thomasy, S. M., & Maggs, D. J. (2016). A review of antiviral drugs and other compounds with activity against feline herpesvirus type 1. Veterinary Ophthalmology, 19(1), 119-130. doi: 10.1111/vop.12375
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2022-01-10
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Silva, D. S. e, Castro, C. C. de, Silva, F. da S. e, Grecco, F. B., Fonseca, R. N. da, Fischer, G., … Hübner, S. de O. (2022). Experimental infection of BALB/c mice with felid alphaherpesvirus 1. Semina: Ciências Agrárias, 43(1), 51–60. https://doi.org/10.5433/1679-0359.2022v43n1p51
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