Estimulação do sistema metabolizador de drogas hepático do rato, por DDT
DOI:
https://doi.org/10.5433/1679-0359.1984v5n16p26Keywords:
Drug-metabolism, Microsoma, Chlorinated insecticides, Enzyme induction.Abstract
A single dose do DDT (DichlorodiphenyltrichloroethaneJ (50 and 100 mg/kg i.p.) enhanced the hepatic metabolizing activity in rats. The N-demethylation ofaminopyrine showed a 3-4 fold increase when compared with control On the other hand, there was only a 2-fold increase on hydroxyltion of aniline and on the levels of cytochrome PA s 0. The pentobarbital sleeping time decreased 80% in both doses of insecticide. These results revealed a maximal induction in the dose of 50 mg/kg of insecticide. In adition, it was demonstrated that the DDT evokes a diferential effect on the aminopyrine N-demethylase and aniline p-hydroxylase activity.
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