Epidemiological and pathologic aspects of extra-skeletal osteosarcoma in dogs
DOI:
https://doi.org/10.5433/1679-0359.2019v40n6Supl2p3089Keywords:
Mammary gland, Neoplasms Sarcomas, Soft tissues.Abstract
Extra-skeletal osteosarcoma is a malignant mesenchymal neoplasm that originates from soft tissue. This tumor occurs spontaneously in dogs, but there are few cases described in the literature. The objective of this study was to describe the epidemiological and pathologic features of extra-skeletal osteosarcoma in 36 dogs. Cases diagnosed as osteosarcoma affecting dogs (n=216), during 2006 to 2016 were reviewed. Of these, 36 cases were diagnosed as extra-skeletal osteosarcoma. The mean age of affected dogs was 10.4 years, and the mean weight was 19.5kg. No breed predisposition was observed. The most frequently affected sites were the mammary glands (80.6%; 29/36), subcutaneous tissue (5.6%; 2/36), liver (5.6%; 2/36), spleen (2.8%; 1/36), omentum (2.8%; 1/36), and kidney (2.8%; 1/36). Histological examination revealed that 61.1% (22/36) of the tumors were osteoblastic, 33.3% (12/36) chondroblastic, 2.8% (1/36) fibroblastic, and 2.8% (1/36) were giant cell-rich osteosarcomas. Histological grade II and III were the most frequent. Lymph node metastases were observed in 21.4% (3/14) of the cases of mammary gland osteosarcoma. Distant metastases were observed in 23.1% (3/13) of cases by diagnostic imaging and in 71.4% (5/7) during autopsy. Metastases were observed in the lungs (57.1%; 4/7), liver (14.3%; 1/7), spleen (14.3%; 1/7), and in multiple sites (14.3%; 1/7). Pulmonary metastases were more frequently observed in cases of mammary gland osteosarcoma.Downloads
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References
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GÂRJOABĂ, I.; TUDOR, N.; SOARE, T.; TĂNASE, A.; VLĂGIOIU, C. Extraskeletal osteosarcoma in dogs: presentation of two cases. Lucrari Stiintifice-Universitatea de Stiinte Agricole a Banatului Timisoara, Medicina Veterinara, Timisoara, v. 42, n. 2, p. 107-110, 2009.
HEATH, S.; RANKIN, A. J.; DUBIELZIG, R. R. Primary ocular osteosarcoma in a dog. Veterinary Ophthalmology, Osney Mead, v. 6, n. 1, p. 85-87, 2003. DOI: 10.1046/j.1463-5224.2003.00256.x.
HILLERS, K. R.; DERNELL, W. S.; LAFFERTY, M. H.; WITHROW, S. J.; LANA, S. E. Incidence and prognostic importance of lymph node metastases in dogs with appendicular osteosarcoma: 228 cases (1986–2003). Journal of the American Veterinary Medical Association, Schaumburg, v. 226, n. 8, p. 1364-1367, 2005. DOI: 10.2460/javma.2005.226.1364.
KALLIANPUR, A. A.; GUPTA, R.; MUDULY, D. K.; KAPALI, A.; SUBBARAO, K. C. Osteosarcoma of breast: a rare case of extraskeletal osteosarcoma. Journal of Cancer Research and Therapeutics, Mumbai, v. 9, n. 2, p. 292-294, 2013. DOI: 10.4103/0973-1482.113392.
KIRPENSTEIJN, J.; KIK, M.; RUTTEMAN, G. R.; TESKE, E. Prognostic significance of a new histologic grading system for canine osteosarcoma. Veterinary Pathology, Thousand Oaks, v. 39, n. 2, p. 240-246, 2002. DOI: 10.1354/vp.39-2-240.
KUNTZ, C. A.; DERNELL, W. S.; POWERS, B. E.; WITHROW, S. Extraskeletal osteosarcomas in dogs: 14 cases. Journal of the American Animal Hospital Association, South Bend, v. 34, n. 1, p. 26-30, 1998. DOI: 10.5326/15473317-34-1-26.
LANGENBACH, A.; ANDERSON, M. A.; DAMBACH, D. M.; SORENMO, K. U.; SHOFER, F. D. Extraskeletal osteosarcomas in dogs: a retrospective study of 169 cases (1986-1996). Journal of the American Animal Hospital Association, South Bend, v. 34, n. 2, p. 113-120, 1998. DOI: 10.5326/15473317-34-2-113.
LEE, J. S.; FETSCH, J. F.; WASDHAL, D. A.; LEE, B. P.; PRITCHARD, D. J.; NASCIMENTO, A. G. A review of 40 patients with extraskeletal osteosarcoma. Cancer, Hoboken, v. 76, n. 11, p. 2253-2259, 1995. DOI: 10.1002/1097-0142(19951201)76:11<2253::AID-CNCR2820761112>3.0.CO;2-8.
LOUKOPOULOS, P.; ROBINSON, W. F. Clinicopathological relevance of tumour grading in canine osteosarcoma. Journal of Comparative Pathology, London, v. 136, n. 1, p. 65-73, 2007. DOI: 10.1016/j.jcpa.2006.11.005.
PATNAIK, A. K. Canine extraskeletal osteosarcoma and chondrosarcoma: a clinicopathologic study of 14 cases. Veterinary Pathology, Thousand Oaks, v. 27, n. 1, p. 46-55, 1990. DOI: 10.1177/030098589002700107.
SCHOTT, C. R.; TATIERSKY, L. J.; FOSTER, R. A.; WOOD, G. A. Histologic grade does not predict outcome in dogs with appendicular osteosarcoma receiving the standard of care. Veterinary Pathology, Thousand Oaks, v. 55, n. 2, p. 202-211, 2018. DOI: 10.1177/0300985817747329.
SLAYTER, M. V.; BOOSINGER, T. R.; POOL, R. R.; DAMMRICH, K.; MISDORP, W.; LARSEN, S. Histological classification of bone and joint tumors of domestic animals. In: SLAYTER, M. V.; BOOSINGER, T. R.; POOL, R. R.; DAMMRICH, K.; MISDORP, W.; LARSEN, S. (Ed.). International histological classification of tumors of domestic animals. 2nd ed. Washington: Armed Forces Institute of Pathology, American Registry of Pathology and World Health Organization, 1994. p. 1-50. v. 1.
SPUGNINI, E. P.; RUSLANDER, D.; BARTOLAZZI, A. Extraskeletalosteosarcoma in a cat. Journal of the American Veterinary Medical Association, Schaumburg, v. 219, n. 1, p. 60-62, 2001. DOI: 10.2460/javma.2001.219.60.
THOMPSON, K. G.; DITTMER, K. Tumors of bone. In: MEUTEN, D. J. Tumors in domestic animals. 5th ed. Ames: John Wiley & Sons Inc, 2017. 989 p. p. 356-424.
WOLDEMESKEL, M. W.; GRICE, C. D. Pathology in practice. Journal of the American Veterinary Medical Association, Schaumburg, v. 238, n. 3, p. 297-299, 2011. DOI: 10.2460/javma.238.3.297.
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Published
2019-09-30
How to Cite
Guim, T. N., Cecco, B. S. de, Laisse, C. J. M., Schmitt, B., Henker, L. C., Vieira, C. da R., … Sonne, L. (2019). Epidemiological and pathologic aspects of extra-skeletal osteosarcoma in dogs. Semina: Ciências Agrárias, 40(6Supl2), 3089–3098. https://doi.org/10.5433/1679-0359.2019v40n6Supl2p3089
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