Necrotizing leukoencephalitis in a Yorkshire dog from Brazil
DOI:
https://doi.org/10.5433/1679-0359.2019v40n6Supl2p3321Keywords:
Necrotizing encephalitis, Dog, Neuropathology.Abstract
Necrotizing leukoencephalitis (NLE) is an uncommon inflammatory condition of brain of dogs, and was described in dogs from North America, Europe, and Asia. Cases of NLE from South America were not located when major data bases were examined. Consequently, this report describes the findings associated with NLE in a Brazilian 3.5-year-old female Yorkshire dog with neurological findings related to the myelencephalon; the dog died, besides medical treatment, and was submitted for autopsy exam and histopathological evaluation. Lesions were restricted to the encephalon and characterized as leukoencephalomalacia with severe non-suppurative inflammation with extensive perivascular cuffing; the non-suppurative inflammation was characterized by influx of lymphocytes and histiocytes, and occasionally plasma cells, and gitter cells. Infectious disease agents were not identified by molecular techniques or visualized with histochemical stains. This report represents the first definitive diagnose of NLE in Brazil, suggesting that this disease may be present in South America dogs suffering from neurological conditions. This knowledge may be useful for veterinarians in Brazil, taking into account that this disease should be considered as a differential diagnosis when infectious causes are excluded.References
COOPER, J. J.; SCHATZBERG, S. J.; VERNAU, K. M.; SUMMERS, B. A.; PORTER, B. F.; SISO, S.; YOUNG, B. D.; LEVINE, J. M. Necrotizing meningoencephalitis in atypical dog breeds: a case series and literature review. Journal of Veterinary Internal Medicine, Malden, v. 28, n. 1, p. 198-203, 2014. DOI: 10.1111/jvim.12233
HOSOMI, F. Y. M.; RAMOS, A. T.; MASUDA, E. K.; TROST, M. E.; GRAÇA, D. L.; MAIORKA, P. C. Aspectos clínico-patológicos em casos de meningoencefalite necrosante canina. Clínica Veterinária, São Paulo, v. 14, n. 81, p. 62-68, 2009.
JUNG, D. I.; LEE, H. C.; HA, J.; JUNG, H. W.; JEON, J. H.; MOON, J. H.; LEE, J. H.; KIM, N. H.; SUR, J. H.; KANG, B. T.; CHO, K. W. Unsuccessful cyclosporine plus prednisolone therapy for autoimmune meningoencephalitis in three dogs. The Journal of Veterinary Medical Science, Tokyo, v. 75, n. 12, p. 1661-1665, 2013. DOI: 10.1292/jvms.12-0503
KIM, B.; YI, K.; JUNG, S.; JI, S.; CHOI, M.; YOON, J. Clinical applications and characteristics of apparent diffusion coefficient maps for the brain of two dogs. Journal of Veterinary Science, Seoul, v. 15, n. 3, p. 455-458, 2014. DOI: 10.4142/jvs.2014.15.3.455
KUWAMURA, M.; ADACHI, T.; YAMATE, J.; KOTANI, T.; OHASHI, F.; SUMMERS, B. A. Necrotizing encephalitis in the Yorkshire terrier: a case report and literature review. The Journal of Small Animal Practice, Oxford, v. 43, n. 10, p. 459-463, 2002. DOI: 10.1111/j.1748-5827.2002.tb00014.x
LEZMI, S.; TOUSSAINT, Y.; PRATA, D.; LEJEUNE, T.; FERREIRA-NEVES, P.; RAKOTOVAO, F.; FONTAINE, J. J.; MARCHAL, T.; CORDONNIER, N. Severe necrotizing encephalitis in a Yorkshire terrier: topographic and immunohistochemical study. The Journal of Veterinary Medical Science, Tokyo, v. 54, n. 4, p. 186-190, 2007. DOI: 10.1111/j.1439-0442.2007.00925.x
PARK, E. S.; UCHIDA, K.; NAKAYAMA, H. Comprehensive immunohistochemical studies on canine necrotizing meningoencephalitis (NME), necrotizing leukoencephalitis (NLE), and granulomatous meningoencephalitis (GME). Veterinary Pathology, Thousand Oaks, v. 49, n. 4, p. 682-693, 2014. DOI: 10.1177/0300985811429311
SCHATZBERG, S. J.; HALEY, N. J.; BARR, S. C.; DE LAHUNTA, A.; SHARP, N. J. Polymerase chain reaction screening for DNA viruses in paraffin-embedded brains from dogs with necrotizing meningoencephalitis, necrotizing leukoencephalitis, and granulomatous meningoencephalitis. Journal of Veterinary Internal Medicine, Malden, v. 19, n. 4, p. 553-559, 2005. DOI: 10.1111/j.1939-1676.2005.tb02726.x
TIPOLD, A.; FATZER, R.; JAGGY, A.; ZURBRIGGEN, A.; VANDEVELDE, M. Necrotizing encephalitis in Yorkshire terriers. The Journal of Small Animal Practice, Oxford, v. 34, n. 12, p. 623-628, 1993. DOI: 10.1111/j.1748-5827.1993.tb02598.x
VIOTT, A. M.; AEODATO, A.; RAMOS, A. T.; MASUDA, E. K.; MARTINS, T. B.; GRAÇA, D. L. Meningoencefalite necrosante dos Yorkshires. Relato de caso. MEDVEP, Curitiba, v. 5, n. 16, p. 216-220, 2007.
VON PRAUN, F.; MATIASEK, K.; GREVEL, V.; ALEF, M.; FLEGEL, T. Magnetic resonance imaging and pathologic findings associated with necrotizing encephalitis in two Yorkshire terriers. Veterinary Radiology and Ultrasound, Oxford, v. 47, n. 3, p. 260-264, 2006. DOI: 10.1111/j.1740-8261.2006.00137.x
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Semina: Ciências Agrárias
![Creative Commons License](http://i.creativecommons.org/l/by-nc/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Semina: Ciências Agrárias adopts the CC-BY-NC license for its publications, the copyright being held by the author, in cases of republication we recommend that authors indicate first publication in this journal.
This license allows you to copy and redistribute the material in any medium or format, remix, transform and develop the material, as long as it is not for commercial purposes. And due credit must be given to the creator.
The opinions expressed by the authors of the articles are their sole responsibility.
The magazine reserves the right to make normative, orthographic and grammatical changes to the originals in order to maintain the cultured standard of the language and the credibility of the vehicle. However, it will respect the writing style of the authors. Changes, corrections or suggestions of a conceptual nature will be sent to the authors when necessary.