A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli

Authors

  • Rafael Costa Guilhen Universidade do Oeste Paulista
  • Renata Navarro Cassu Universidade do Oeste Paulista
  • Miriely Steim Diniz Universidade do Oeste Paulista
  • Rogério Giuffrida Universidade do Oeste Paulista
  • Rodrigo Rolim Duarte Centro Universitário de Maringá

DOI:

https://doi.org/10.5433/1679-0359.2015v36n6Supl2p4225

Keywords:

Alpha2 adrenoreceptor agonists, Dental, Equine, Opioids.

Abstract

This study aimed to compare the sedative and cardiopulmonary effects of detomidine in combination with saline, morphine or methadone and to determine whether the addition of these opioids increases the degree of sedation in horses submitted to experimental oral stimuli. In a blinded, randomized, experimental study, six adult mares were evaluated using a crossover design with at least 15 days between trials: 10?g/kg detomidine in combination with saline (D/SAL), 0.1mg/kg morphine (D/ MORPH) or 0.1mg/kg methadone (D/METH). The degree of sedation, response to oral stimuli and cardiopulmonary parameters were monitored for 120 minutes. Parametric data were analyzed using the ANOVA and Tukey’s tests, and non- parametric data were analyzed with the Kruskal-Wallis and Friedman’s tests with the post-Dunn test (P<0.05). The degree of sedation was significantly greater for the D/SAL than for the D/MORPH and D/METH treatments at 30 min. The horses´ responses to the oral stimuli decreased significantly following all treatments at 5 and 30 min from baseline values. The heart rate, respiratory rate, arterial pH and blood gas variables were all similar among the treatment groups. Mean arterial blood pressure was significantly higher in the D/MORPH group when compared with the D/SAL group between 75 and 120 min. It was concluded that all treatments provided sedative effects with mild cardiopulmonary changes. However the addition of morphine or methadone to detomidine did not improve the degree of sedation in horses submitted to experimental oral stimuli.

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Author Biographies

Rafael Costa Guilhen, Universidade do Oeste Paulista

Prof., Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, SP, Brasil.

Renata Navarro Cassu, Universidade do Oeste Paulista

Profa, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, SP, Brasil.

Miriely Steim Diniz, Universidade do Oeste Paulista

Discente, Universidade Estadual Paulista, UNESP, Botucatu, SP, Brasil.

Rogério Giuffrida, Universidade do Oeste Paulista

Prof., Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, SP, Brasil.

Rodrigo Rolim Duarte, Centro Universitário de Maringá

Prof., Centro Universitário de Maringá, CESUMAR, Maringá, PR, Brasil.

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Published

2015-12-16

How to Cite

Guilhen, R. C., Cassu, R. N., Diniz, M. S., Giuffrida, R., & Duarte, R. R. (2015). A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli. Semina: Ciências Agrárias, 36(6Supl2), 4225–4236. https://doi.org/10.5433/1679-0359.2015v36n6Supl2p4225

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