Testicular morphometry and stereology of adult rats treated with cyclophosphamide incorporated to the liposome
DOI:
https://doi.org/10.5433/1679-0367.2006v27n2p105Keywords:
Liposome, Cyclophosphamide, Testis, Morphometry, Stereology.Abstract
Liposomes represent a useful drug carrier system which is utilized in clinical studies to act as a non-toxic vehicle, reducing side effects and increasing the efficacy of antitumor agents. The aim of this study is to investigate, by means of morphometric and stereologic parameters, the effects of the cyclophosphamide, incorporated to liposomes, in testis of adult rats. As a result, the incorporation of the oncolytic agent to the liposomes showed, in the first place, increase of the testicular weight and volume, as well as an extension in diameter and area of the seminiferous tubules. For the group treated with cyclophosphamide incorporated to liposomes the differences in testicular and parechyma volumes showed non-significant with respect to the control group. Results indicate that the incorporation of the drug to the liposome reduces side effects on the male gonad.
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