Thermoanalytical studies of cimetidine and complexes with Mn(II) Co(II) and Ni(II)

Thermoanalytical studies of cimetidine and complexes with Mn(II) Co(II) and Ni(II)

Authors

  • Ana Carolina Mendes Hacke Universidade Estadual de Ponta Grossa
  • Fernanda Moreira Universidade Estadual de Ponta Grossa
  • Egon Schnitzler Universidade Estadual de Ponta Grossa
  • Neiva Deliberali Rosso Universidade Estadual de Ponta Grossa

DOI:

https://doi.org/10.5433/1679-0375.2013v34n2p229

Keywords:

Cimetidine, Complex, Thermal stability

Abstract

Cimetidine is an important hydrogen histamine receptor and can coordinate metal ions in blood plasma. The stability of cimetidine and its complexes with Mn(II), Co(II) and Ni(II) was evaluated by studies of thermogravimetry (TG) and differential thermal analysis (DTA). Cimetidine was thermally stable up to near 190 °Cand above this temperature the thermal decomposition occurred in two stages. Complexes of [Mn(HCm)2]Cl2, [Co(Cm)2]Cl2 and [Ni(Cm)2]Cl2 showed a similar behavior. The pyrolytic decomposition occurred in two stages at temperatures above 250 oC. A residue for each complex was detected at the end of the decomposition process. This probably corresponds to the respective metal oxide.

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Author Biographies

Ana Carolina Mendes Hacke, Universidade Estadual de Ponta Grossa

Graduanda, Departamento de Química

Fernanda Moreira, Universidade Estadual de Ponta Grossa

Mestranda em Ciência e Tecnologia de Alimentos, Departamento de Engenharia de Alimentos.

Egon Schnitzler, Universidade Estadual de Ponta Grossa

Depatamento de Química

Neiva Deliberali Rosso, Universidade Estadual de Ponta Grossa

Departamento de Química, Química Inorgânica.

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Published

2014-01-31

How to Cite

Hacke, A. C. M., Moreira, F., Schnitzler, E., & Rosso, N. D. (2014). Thermoanalytical studies of cimetidine and complexes with Mn(II) Co(II) and Ni(II). Semina: Ciências Exatas E Tecnológicas, 34(2), 229–236. https://doi.org/10.5433/1679-0375.2013v34n2p229

Issue

Vol. 34 No. 2 (2013)

Section

Original Article

License

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