Fibrosarcoma arising after femur osteosynthesis with pin and plate placement in a cat
DOI:
https://doi.org/10.5433/1679-0359.2019v40n6p2805Keywords:
Feline, Mesenchymal, Osteosynthesis, Sarcoma.Abstract
A 6-year old spayed female Siamese cat was presented with a history of left limb acute lameness. Radiographic imaging revealed a complete comminuted diaphyseal femur fracture, which was corrected through intramedullary pin placement along with plate osteosynthesis. After two months the animal returned to the hospital presenting severe diffuse enlargement of the left hindlimb, characterized as a non-delimited, solid, and firm plaque-like mass surrounding the pin and bone, which extended from the femorotibiopatelar joint to the pelvis, and infiltrated the adjacent musculature. Incisional biopsy exam indicated a highly malignant sarcoma. The entire limb was surgically removed and sent to histopathological evaluation. Microscopically, the mass was composed of spindle shaped cells, displaying high pleomorphism and cellular atypia. Abundant collagen production was evidenced through Masson's trichrome stain and strong cytoplasmic staining for vimentin. These results were consistent with fibrosarcoma. The cat went through one session of chemotherapy; however, tumor recurrence occurred 20 days later, and the animal was submitted to euthanasia. This is the first description of fibrosarcoma arising in the vicinity of an intramedullary pin and plate in a cat.Downloads
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References
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DALY, M. K.; SABA, C. F.; CROCHIK, S. S.; HOWERTH, E. W.; KOSAREK, C. E.; CORNELL, K. K.; ROBERTS, R. E.; NORTHRUP, N. C. Fibrosarcoma adjacent to the site of microchip implantation in a cat. Journal of Feline Medicine and Surgery, London, v. 10, n. 2, p. 202-205, 2008.
DODDY, F. D.; GLICKMAN, L. T.; GLICKMAN, N. W. Feline fibrosarcomas at vaccination sites and non-vaccination sites. Journal of Comparative Pathology, London, v. 114, n. 2, p. 165-174, 1996.
DUBIELZIG, R. R.; EVERITT, J.; SHADDUCK, A.; ALBERT, M. Clinical and morphologic features of post-traumatic ocular sarcomas in cats. Veterinary Pathology, Washington, v. 27, n. 1, p. 62-65, 1990.
HADDAD, J. L.; GOLDSCHMIDT, M. H.; PATEL, R. T. Fibrosarcoma arising from the site of a retained surgical sponge in a cat. Veterinary Clinical Pathology, Santa Barbara, v. 39, n. 2, p. 241-246, 2010.
HAUCK, M. Feline injection site sarcomas. Veterinary Clinics of North America Small Animal Practice, Philadelphia, v. 33, n. 3, p. 553-557, 2003.
HENDRICK, M. J. Mesenchymal tumors of the skin and soft tissues. In: MEUTEN, D. J. Tumors in domestic animals. 5th ed. Ames: John Wiley & Sons Inc, 2017. p. 142-175.
KANG, S.; SOUTHARD, T.; HUME, K.R. DNA damage is a feature of feline injection-site sarcoma. Veterinary and Comparative Oncology, v. 15, n. 2, p. 518-524, 2017.
KASS, P. H.; SPANGLER, W. L.; HENDRICK, M. J.; MCGILL, L. D.; ESPLIN, G.; LESTER, S.; SLATER, M.; MEYER, E. K.; BOUCHER, F.; PETERS, E. M.; GOBAR, G. G.; HTOO, T.; DECILE, K. Multicenter case control study of risk factors associated with development of vaccine-associated sarcomas in cats. Journal of American Veterinary Medical Association, Schaumburg, v. 223, n. 9, p. 1283-1292, 2003.
KIRKPATRICK, C. J.; ALVES, A.; KOHLER, H.; KRIEGSMANN, J.; BITTINGER, F.; OTTO, M.; WILLIAMS, D. F.; ELOY, R. Biomaterial-induced sarcoma: a novel model to study pre-neoplastic change. American Journal of Pathology, New York, v. 156, n. 4, p. 1455-1467, 2000.
KLICZKOWSKA, K.; JANKOWSKA, U.; JAGIELSKI, D.; CZOPOWICZ, M.; SAPIERZYNSKI, R. Epidemiological and morphological analysis of feline injection site sarcomas. Polish Journal of Veterinary Sciences, Olsztyn, v. 18, n. 2, p. 313-322, 2015.
MOIZHESS, T. G. Carcinogenesis induced by foreign bodies. Biochemistry, New York, v. 73, n. 7, p. 763-775, 2008.
NAMBIAR, P. R.; JACKSON, M. L.; ELLIS, J. A.; CHELACK, J.; KIDNEY, B. A.; HAINES, D. M. Immunohistochemical detection of tumor suppressor gene p53 protein in feline vaccine site-associated sarcomas. Veterinary Pathology, Washington, v. 38, n. 2, p. 236-238, 2001.
RANEN, E.; LAVY, E.; AIZENBERG, I.; PERL, S.; HARRUS, S. Spirocercosis-associated esophageal sarcomas in dogs. A retrospective study of 17 cases (1997-2003). Veterinary Parasitology, Leiden, v. 119, n 2-3, p. 209-221, 2004.
VASCELLARI, M.; MELCHIOTTI, E.; MUTINELLI, F. Fibrosarcoma with typical features of post-injection sarcoma at site of microchip implant in a dog: histologic and immunohistochemical study. Veterinary Pathology, Washington, v. 43, n. 4, p. 545-548, 2006.
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Published
2019-08-29
How to Cite
Cecco, B. S. de, Henker, L. C., Souza, M. de J. de, Vielmo, A., Ferreira, M. P., Gomes, C., … Sonne, L. (2019). Fibrosarcoma arising after femur osteosynthesis with pin and plate placement in a cat. Semina: Ciências Agrárias, 40(6), 2805–2812. https://doi.org/10.5433/1679-0359.2019v40n6p2805
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