Influence of induced inflamation with BCG on the regression of Ehrlich tumour

Authors

  • Ana Paula Frederico Rodrigues Loureiro Bracarense Universidade Estadual de Londrina
  • Idêrcio Luiz Sinhorini Universidade de São Paulo

DOI:

https://doi.org/10.5433/1679-0359.1994v15n1p8

Keywords:

Inflammatio, Neoplasia, Ehrlich, Tumour, BCG.

Abstract

It has been analized the influence of experimentally induced inflamation with BCG on the regression of the solid Ehrlich tumour. The experimental model consisted of the administration of BCG intralesionally. The animals received 0,05ml of a suspension containing 2,5 x 106 tumor cells in the footpad. Histologic changes have been demostrated in the development of the tumour at several times after the inoculation of BCG. Alterations in tumour size have also been studied. Estatistic analysis (Student T-test) has not demonstrated significant levels (5%). The growth of the tumour has re-established accompanying the evolution of the process. This fact suggests that although BCG interferes with tumour's growth it was not able to bring about complete destruction of the neoplasia.

 

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Author Biographies

Ana Paula Frederico Rodrigues Loureiro Bracarense, Universidade Estadual de Londrina

Departamento de Medicina Veterinária Preventiva / Centro de Ciências Agrárias / Universidade Estadual de Londrina, Caixa Postal 6001, CEP 86051-970, Londrina-PR. Telefone: (043) 321-2000, ramal 4485.

Idêrcio Luiz Sinhorini, Universidade de São Paulo

 

Departamento de Patologia Animal / Universidade de São Paulo. São Paulo - SP.

Published

1994-01-15

How to Cite

Bracarense, A. P. F. R. L., & Sinhorini, I. L. (1994). Influence of induced inflamation with BCG on the regression of Ehrlich tumour. Semina: Ciências Agrárias, 15(1), 8–13. https://doi.org/10.5433/1679-0359.1994v15n1p8

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