Seroprevalence and risk factors associated with Neospora caninum in commercial sheep from northwest of Rio Grande do Sul, Brazil
DOI:
https://doi.org/10.5433/1679-0359.2020v41n2p703Keywords:
Neosporosis, RIFI, Serology, Sheep.Abstract
Neospora caninum is a widely distributed parasite, which significantly impacts reproduction in ruminants. This study aimed to survey the seroprevalence and risk factors associated with neosporosis infection in commercial herds of sheep in the northwest of Rio Grande do Sul, Brazil. Three hundred sheep serum samples were used to investigate anti-N. caninum antibodies using indirect immunofluorescence reaction at a 1:40 dilution. The presence of anti-N. caninum antibodies was detected in 20.3% (61/300) of the samples evaluated; however, positive reactions were observed in all (13/13) flocks sampled. Sheep breeds > 1 year of age had 1.2-fold higher risk for infection with N. caninum (odds ratio 2.2 [95% confidence interval 1-5.1]; P < 0.001). These findings should raise awareness on the importance of serological screening, identification of risk factors, and maintenance of preventive measures, such as not allowing dogs to contact sheep feed and not offering the placental remains of ruminants to canids.References
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Faria, E. B., Cavalcanti, E. F. T. S. F., Medeiros, E. S., Pinheiro, J. W., Jr., Azevedo, S. S., Athayde, A. C. R., & Mota, R. A. (2010). Risk factors associated with Neospora caninum seropositivity in sheep from the State of Alagoas, in the Northeast Region of Brazil. Journal of Parasitology, 96(1), 197-199. doi: 10.1645/GE-2176.1
Ferreira, M. S. T., Vogel, F. S. F., Sangioni, L. A., Cezar, A. S., & Menezes, F. R. de. (2016). Neospora spp. and Toxoplasma gondii infection in sheep flocks from Rio Grande do Sul, Brazil. Semina: Ciências Agrárias, 37(3), 1397-1406. doi: não tem
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Hecker, Y. P., Masson, F. M., Armendano, J. I., Cora, J., Olivares, C. F., Gual, I., Cantón, G. J. (2018). Evaluation of frequency of antibodies against Toxoplasma gondii, Neospora caninum and Sarcocystis spp. and transmission routes in sheep from Humid Pampa, Argentina. Acta Parasitológica, 63(2), 416-421. doi: 10.1515/ap-2018-0048
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Machado, G. P., Kikuti, M., Langoni, H., & Paes, A. C (2011). Seroprevalence and risk factors associated with neosporosis in sheep and dogs from farms. Veterinary Parasitology, 182(2-4), 356-358. doi: 10.1016/j.vetpar.2011.05.021
McAllister, M. M., Dubey, J. P., Lindsay, D. S., Jolley, W. R., Wills, R. A., McGuire, A. M. (1998). Dogs are definitive hosts of Neospora caninum. International journal for parasitology. 28(9), 1473-1478. doi: https://doi.org/10.1016/S0020-7519(98)00138-6
Moraes, L. M. de B., Raimundo, J. M., Guimarães, A., Santos, H. A., Macedo, G. L., Jr., Lima, G. de, . . . Baldani, C. D. (2011). Occurrence of anti-Neospora caninum and anti-Toxoplasma gondii IgG antibodies in goats and sheep in western Maranhão, Brazil. Revista Brasileira de Parasitologia Veterinária, 20(4), 312-317. doi: 10.1590/S1984-29612011000400010
Moreno, B., Collantes-Fernández, E., Villa, A., Navarro, A., Regidor-Cerrillo, J., & Ortega-Mora, L. M. (2012). Occurrence of Neospora caninum and Toxoplasma gondii infections in ovine and caprine abortions. Veterinary Parasitology, 187(1-2), 312-318. doi: 10.1016/j.vetpar.2011.12.034
Moura, A. B. de, Güths, M. F., Farias, J. A., Souza, A. P. de, Sartor, A. A., & Quadros, R. M. de. (2014). Neospora caninum seroprevalence and risk factors for ewes from Santa Catarina Plateau, Brazil. Semina: Ciências Agrárias, 35(5), 2591-2600. doi: 10.5433/1679-0359.2014v35n5p2591
Munhoz, K. F., Luca, M., Neto, Santos, S., M. A., Garcia, J. L., Guimaraes Junior, J. S., Vidotto, O., . . . Yamamura, M. H. (2010). Occurrence of anti-Neospora caninum antibodies in sheep from farms located in northern Paraná, Brazil. Semina: Ciências Agrárias, 31(4), 1031-1039. doi: Não tem
Nie, L.-B., Cong, W., Zou, Y., Zhou, D.-H., Liang, Q.-L., Zheng, W.-B., . . . Zhu, X.-Q. (2018). First report of seroprevalence and risk factors of Neospora caninum infection in tibetan sheep in China. BioMed research international, 2018(1), 1-4. doi: 10.1155/2018/2098908
Nunes, A. C. B. T., Yamasaki, E. M., Kim, P. C. P., Melo, R. P. B., Ribeiro-Andrade, M., Porto, W. J. N., Mota, R. A. (2017). Transplacental transmission of Neospora caninum in naturally infected small ruminants from northeastern Brazil. Pesquisa Veterinária Brasileira, 37(9), 921-925. https://doi.org/10.1590/s0100-736x2017000900004
Razmi, G., & Naseri, Z. (2017). Molecular detection of Neospora caninum infection in ovine aborted foetuses in the Mashhad area, Iran. Annals of parasitology, 63(1), 45-47. doi: nome da Revista por extenso.
Reichel, M. P., Ross, G. P., & McAllister, M. M. (2008). Evaluation of an enzyme-linked immunosorbent assay for the serological diagnosis of Neospora caninum infection in sheep and determination of the apparent prevalence of infection in New Zealand. Veterinary Parasitology, 151(2-4), 323-326. doi: 10.1016/j.vetpar.2007.11.002
Rizzo, H., Jesus, T. K. S. de, Gaeta, N. C., Carvalho, J. S., Pinheiro, J. W., Jr., Gregory, L., & Villalobos, E. M. C. (2017). Pesquisa de anticorpos IgG para Neospora caninum e avaliação dos fatores de risco em ovinos do Estado de Sergipe. Pesquisa Veterinária Brasileira, 37(8), 813-819. doi: 10.1590/s0100-736x2017000800006
Rizzo, H., Villalobos, E. M. C., Meira, E. B. S., Jr., Marques, E. C., Beraldi, F., & Gregory, L. (2018). Ocorrência de anticorpos anti-Toxoplasma gondii e anti-Neospora caninum em ovinos com distúrbios reprodutivos e fatores de risco. Pesquisa Veterinária Brasileira, 38(2), 1317-1326. doi: 10.1590/1678-5150-pvb-4174
Salaberry, S. R. S., Okuda, L. H., Nassar, A. F. de C., Castro, J. R. de, & Lima-Ribeiro, A. M. C. (2010). Prevalence of Neospora caninum antibodies in sheep flocks of Uberlândia county, MG. Revista Brasileira de Parasitologia Veterinária, 19(3), 148-151. doi: 10.1590/S1984-29612010000300004
Souza, O. L., Neto, Albuquerque, P. P. F., Santos, A. S., Fernandes, E. F. T. S., Faria, E. B., Moraes, E. P. B. X., . . . Mota, R. A. (2009). Prevalência de anticorpos IgG anti-Neospora caninum e fatores de risco associados à infecção em ovinos no município de Gravatá, Pernambuco, Brasil. Anais Jornada de Ensino, Pesquisa e Extensão (JEPEX), Recife, PE, Brasil. 9.
Villagra-Blanco, R., Barrantes-Granados, O., Montero-Caballero, D., Romero-Zúñiga, J. J., & Dolz, G. (2019). Seroprevalence of Toxoplasma gondii and Neospora caninum infections and associated factors in sheep from Costa Rica. Parasite Epidemiology and Control, 4(10), e00085. doi: 10.1016/j.parepi.2019.e00085
Vogel, F. S. F., Arenhart, S., & Bauermann, F. V. (2006). Antibodies to Neospora caninum in cattle, sheep and water buffalo in Rio Grande do Sul state, Brazil. Ciência Rural, 36(4), 1948-1951. doi: 10.1590/S0103-84782006000600048
Wang, S., Li, L., Lu, Y., Zhang, H., Xie, Q., & Zhang, Z. (2018). Seroprevalence and risk factors of Neospora caninum infection among domestic sheep in Henan province, central China. Parasite, 25(15), 1-5. doi: 10.1051/parasite/2018019
Cerqueira-Cézar, C. K., Calero-Bernal, R., Dubey, J. P., Gennari, S. M., Cerqueira-Cézar, C. K., Calero-Bernal, R., . . . Gennari, S. M. (2017). All about neosporosis in Brazil. Revista Brasileira de Parasitologia Veterinária, 26(3), 253-279. doi: 10.1590/s1984-29612017045
Choi, B. C. K., & Pak, A. W. P. A. (2004). Catalog of biases in questionnaires. Preventing Chronic Disease, 2(1), 1-13. Recuperado de https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1323316/
Corbellini, L. G., Driemeier, D., Cruz, C. F. E., Gondim, L. F. P., & Wald, V. (2002). Neosporosis as a cause of abortion in dairy cattle in Rio Grande do Sul, southern Brazil. Veterinary Parasitology, 103(3), 195-202. doi: 10.1016/S0304-4017(01)00600-8
Corbellini, L. G., Pescador, C. A., Frantz, F., Wunder, E., Steffen, D., Smith, D. R., & Driemeier, D. (2006). Diagnostic survey of bovine abortion with special reference to Neospora caninum infection: Importance, repeated abortion and concurrent infection in aborted fetuses in Southern Brazil. The Veterinary Journal, 172(1), 114-120. doi: 10.1016/j.tvjl.2005.03.006
Cosendey, R. I. J., Oliveira, F. C. R. de, Frazão-Teixeira, E., Souza, G. N. de, Brandão, F. Z., Ferreira, A. M. R., & Lilenbaum, W. (2018). Seroprevalence of anti-Neospora caninum antibodies in sheep from the rapidly expanding flock of Rio de Janeiro, Brazil. Veterinary Parasitology: Regional Studies and Reports, 14(10), 59-62. doi: 10.1016/j.vprsr.2018.09.001
Dubey, J. P., Barr, B. C., Barta, J. R., Bjerkås, I., Björkman, C., Blagburn, B. L., . . . Lindsay, D. S. (2002). Redescription of Neospora caninum and its differentiation from related coccidia. International Journal for Parasitology, 32(8), 929-946. doi: 10.1016/S0020-7519(02)00094-2
Dubey, J. P., & Schares, G. (2011). Neosporosis in animals the last five years. Veterinary Parasitology, 180(1-2), 90-108. doi: 10.1016/j.vetpar.2011.05.031
Faria, E. B., Cavalcanti, E. F. T. S. F., Medeiros, E. S., Pinheiro, J. W., Jr., Azevedo, S. S., Athayde, A. C. R., & Mota, R. A. (2010). Risk factors associated with Neospora caninum seropositivity in sheep from the State of Alagoas, in the Northeast Region of Brazil. Journal of Parasitology, 96(1), 197-199. doi: 10.1645/GE-2176.1
Ferreira, M. S. T., Vogel, F. S. F., Sangioni, L. A., Cezar, A. S., & Menezes, F. R. de. (2016). Neospora spp. and Toxoplasma gondii infection in sheep flocks from Rio Grande do Sul, Brazil. Semina: Ciências Agrárias, 37(3), 1397-1406. doi: não tem
Filho, P. C. G. A., Oliveira, J. M. B., Andrade, M. R., Silva, J. G., Kim, P. C. P., Almeida, J. C., Mota, R. A. (2017). Incidence and vertical transmission rate of Neospora caninum in sheep. Comparative Immunology, Microbiology and Infectious Diseases, 52(4), 19-22. doi: 10.1016/j.cimid.2017.05.006 Corrigir o nome do autor: FILHO não é sobrenome. Corrigir a citação no texto- Resposta: no artigo está como sobrenome e citação sugerida Filho et al.
Hecker, Y. P., Masson, F. M., Armendano, J. I., Cora, J., Olivares, C. F., Gual, I., Cantón, G. J. (2018). Evaluation of frequency of antibodies against Toxoplasma gondii, Neospora caninum and Sarcocystis spp. and transmission routes in sheep from Humid Pampa, Argentina. Acta Parasitológica, 63(2), 416-421. doi: 10.1515/ap-2018-0048
Instituto Brasileiro de Geografia e Estatística. (2014). Efetivo do rebanho de ovinos em 2014. Brasília, IBGE. Recuperado de http://www.ibge.gov.br/home/
Machado, G. P., Kikuti, M., Langoni, H., & Paes, A. C (2011). Seroprevalence and risk factors associated with neosporosis in sheep and dogs from farms. Veterinary Parasitology, 182(2-4), 356-358. doi: 10.1016/j.vetpar.2011.05.021
McAllister, M. M., Dubey, J. P., Lindsay, D. S., Jolley, W. R., Wills, R. A., McGuire, A. M. (1998). Dogs are definitive hosts of Neospora caninum. International journal for parasitology. 28(9), 1473-1478. doi: https://doi.org/10.1016/S0020-7519(98)00138-6
Moraes, L. M. de B., Raimundo, J. M., Guimarães, A., Santos, H. A., Macedo, G. L., Jr., Lima, G. de, . . . Baldani, C. D. (2011). Occurrence of anti-Neospora caninum and anti-Toxoplasma gondii IgG antibodies in goats and sheep in western Maranhão, Brazil. Revista Brasileira de Parasitologia Veterinária, 20(4), 312-317. doi: 10.1590/S1984-29612011000400010
Moreno, B., Collantes-Fernández, E., Villa, A., Navarro, A., Regidor-Cerrillo, J., & Ortega-Mora, L. M. (2012). Occurrence of Neospora caninum and Toxoplasma gondii infections in ovine and caprine abortions. Veterinary Parasitology, 187(1-2), 312-318. doi: 10.1016/j.vetpar.2011.12.034
Moura, A. B. de, Güths, M. F., Farias, J. A., Souza, A. P. de, Sartor, A. A., & Quadros, R. M. de. (2014). Neospora caninum seroprevalence and risk factors for ewes from Santa Catarina Plateau, Brazil. Semina: Ciências Agrárias, 35(5), 2591-2600. doi: 10.5433/1679-0359.2014v35n5p2591
Munhoz, K. F., Luca, M., Neto, Santos, S., M. A., Garcia, J. L., Guimaraes Junior, J. S., Vidotto, O., . . . Yamamura, M. H. (2010). Occurrence of anti-Neospora caninum antibodies in sheep from farms located in northern Paraná, Brazil. Semina: Ciências Agrárias, 31(4), 1031-1039. doi: Não tem
Nie, L.-B., Cong, W., Zou, Y., Zhou, D.-H., Liang, Q.-L., Zheng, W.-B., . . . Zhu, X.-Q. (2018). First report of seroprevalence and risk factors of Neospora caninum infection in tibetan sheep in China. BioMed research international, 2018(1), 1-4. doi: 10.1155/2018/2098908
Nunes, A. C. B. T., Yamasaki, E. M., Kim, P. C. P., Melo, R. P. B., Ribeiro-Andrade, M., Porto, W. J. N., Mota, R. A. (2017). Transplacental transmission of Neospora caninum in naturally infected small ruminants from northeastern Brazil. Pesquisa Veterinária Brasileira, 37(9), 921-925. https://doi.org/10.1590/s0100-736x2017000900004
Razmi, G., & Naseri, Z. (2017). Molecular detection of Neospora caninum infection in ovine aborted foetuses in the Mashhad area, Iran. Annals of parasitology, 63(1), 45-47. doi: nome da Revista por extenso.
Reichel, M. P., Ross, G. P., & McAllister, M. M. (2008). Evaluation of an enzyme-linked immunosorbent assay for the serological diagnosis of Neospora caninum infection in sheep and determination of the apparent prevalence of infection in New Zealand. Veterinary Parasitology, 151(2-4), 323-326. doi: 10.1016/j.vetpar.2007.11.002
Rizzo, H., Jesus, T. K. S. de, Gaeta, N. C., Carvalho, J. S., Pinheiro, J. W., Jr., Gregory, L., & Villalobos, E. M. C. (2017). Pesquisa de anticorpos IgG para Neospora caninum e avaliação dos fatores de risco em ovinos do Estado de Sergipe. Pesquisa Veterinária Brasileira, 37(8), 813-819. doi: 10.1590/s0100-736x2017000800006
Rizzo, H., Villalobos, E. M. C., Meira, E. B. S., Jr., Marques, E. C., Beraldi, F., & Gregory, L. (2018). Ocorrência de anticorpos anti-Toxoplasma gondii e anti-Neospora caninum em ovinos com distúrbios reprodutivos e fatores de risco. Pesquisa Veterinária Brasileira, 38(2), 1317-1326. doi: 10.1590/1678-5150-pvb-4174
Salaberry, S. R. S., Okuda, L. H., Nassar, A. F. de C., Castro, J. R. de, & Lima-Ribeiro, A. M. C. (2010). Prevalence of Neospora caninum antibodies in sheep flocks of Uberlândia county, MG. Revista Brasileira de Parasitologia Veterinária, 19(3), 148-151. doi: 10.1590/S1984-29612010000300004
Souza, O. L., Neto, Albuquerque, P. P. F., Santos, A. S., Fernandes, E. F. T. S., Faria, E. B., Moraes, E. P. B. X., . . . Mota, R. A. (2009). Prevalência de anticorpos IgG anti-Neospora caninum e fatores de risco associados à infecção em ovinos no município de Gravatá, Pernambuco, Brasil. Anais Jornada de Ensino, Pesquisa e Extensão (JEPEX), Recife, PE, Brasil. 9.
Villagra-Blanco, R., Barrantes-Granados, O., Montero-Caballero, D., Romero-Zúñiga, J. J., & Dolz, G. (2019). Seroprevalence of Toxoplasma gondii and Neospora caninum infections and associated factors in sheep from Costa Rica. Parasite Epidemiology and Control, 4(10), e00085. doi: 10.1016/j.parepi.2019.e00085
Vogel, F. S. F., Arenhart, S., & Bauermann, F. V. (2006). Antibodies to Neospora caninum in cattle, sheep and water buffalo in Rio Grande do Sul state, Brazil. Ciência Rural, 36(4), 1948-1951. doi: 10.1590/S0103-84782006000600048
Wang, S., Li, L., Lu, Y., Zhang, H., Xie, Q., & Zhang, Z. (2018). Seroprevalence and risk factors of Neospora caninum infection among domestic sheep in Henan province, central China. Parasite, 25(15), 1-5. doi: 10.1051/parasite/2018019
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2020-03-06
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Consalter, A., Silva, A. F. da, Gaia, V. G., Zanella, E. L., Souza, G. N. de, & Ferreira, A. M. R. (2020). Seroprevalence and risk factors associated with Neospora caninum in commercial sheep from northwest of Rio Grande do Sul, Brazil. Semina: Ciências Agrárias, 41(2), 703–710. https://doi.org/10.5433/1679-0359.2020v41n2p703
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