Cytological, histopathological, histochemical, and immunohistochemical findings of multiple cutaneous nodules in a bovine
DOI:
https://doi.org/10.5433/1679-0359.2019v40n6Supl3p3781Keywords:
Dermatopathies, Eosinophilic inflammation, Granulomatous inflammation, Peripheral nerve sheath tumor, Ruminant.Abstract
This case study describes the cytological and histopathological findings of cutaneous masses in a bovine, including a peripheral nerve sheath tumor (PNST), vaccine-associated granulomatous inflammation, and eosinophilic inflammation due to parasitosis. A six-year-old undefined cow (SRD) presented with heterogeneous cutaneous lesions including multiple nodules in the left paralumbar fossa, bilaterally at the withers, and scattered along the dorsum, limbs and near the tail; some lesions were associated with ticks. Cytology of these nodules showed benign mesenchymal neoplasia (paralumbar fossa), granulomatous and pyogranulomatous inflammation (withers) and keratin (dorsum). Histopathology, in this order, confirmed PNST, post-vaccination granuloma, and eosinophilic dermatitis. A peripheral nerve sheath tumor was suspected based on the histological findings, showing a well-delineated proliferation of fusiform cells arranged in plexiform structures, which appeared red by Masson's Trichrome stain. The diagnosis was confirmed by immunohistochemistry (anti-S100 antibody). Vaccine reaction often occurs in cattle, and cytological examination is sufficient to determine the inflammatory process. Eosinophilic dermatitis is usually accompanied by perivascular inflammation and reflects the exfoliative process by the oral apparatus of the parasite.Downloads
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References
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BABOVIC-VUKSANOVIC, D.; PETROVIC, L.; KNUDSEN, B. E.; PLUMMER, T. B.; PARISI, J. E.; BABOVIC, S.; PLATT, J. L. Survival of human neurofibroma in immunodeficient mice and initial results of therapy with pirfenidone. Journal of Biomedicine and Biotechnology, Bethesda, v. 2004, n. 2, p. 79-85, 2004. DOI: 10.1155 / S1110724304308107
CANFIELD, P. The ultrastructure of bovine peripheral nerves heath tumours. Veterinary Pathology, California, v. 15, ed. 3, p. 292-300, 1978. DOI: 10.1177/030098587801500303
GASHAW, B. A.; MERSHA, C. K. Pathology of tick bite lesions in naturally infested skin and hides of ruminants: A Review. Acta Parasitologica Globalis, Dubai, v. 4, n. 2, p. 59-63, 2013. DOI: 10.20372/1547201119.01
LUCENA, R. B.; RISSI, D. R.; KOMMERS, G. D.; PIEREZAN, F.; OLIVEIRA-FILHO, J. C.; MACÊDO, J. T.; FLORES, M. T.; BARROS, C. S. A retrospective study of 586 tumours in Brazilian cattle. Journal of Comparative Pathology, England, v. 145, n. 1, p. 20-24, 2011. DOI: 10.1016 / j.jcpa.2010.11.002
SCHÖNIGER, S.; SUMMERS, B. A. Localized, plexiform, diffuse, and other variants of neurofibroma in 12 dogs, 2 horses, and a chicken. Journal Veterinary Pathology, São Paulo, v. 46, n. 5, p. 904-915, 2009. DOI: 10.1354 / vp.08-VP-0322-S-FL
SCRUGGS, J. L.; LEBLANC, C. J. Identification of blue staining vaccine-derived material in inflammatory lesions using cultured canine macrophages. Veterinary Clinical Pathology, New Jersey, v. 44, n. 1, p. 152-156, 2015. DOI: 10.1111 / vcp.12228
SPICKLER, A. R.; ROTH, J. A. Adjuvants in veterinary vaccines: modes of action and adverse effects. Journal of Veterinary Internal Medicine, United States, v. 17, n. 3, p. 273-281, 2003. DOI: 10.1111 / j.1939-1676.2003.tb02448.x
MAULDIN, E. A.; PETERS-KENNEDY, J. Integumentary system. In: MAXIE, M. G. (Ed.). Jubb, Kennedy, and Palmer’s pathology of domestic animals. 6. ed. St. Louis: Elsevier, 2016. p. 511-580.
WHITE, S. D.; EVANS, A. G. Alterações na pele. In: SMITH, B. P. Medicina interna de grandes animais. 3. ed. São Paulo: Manole, 2006. p. 182-206.
WIEDMEYER, C. E.; FANGMAN, T. J.; SCHWARTZ, K.; PAYNE, B. Fine-needle aspiration and cytology as an antemortem method for evaluating in jection-site lesions. Journal Swine Health and Production, Iowa, v. 22, n. 4, p. 244-247, 2014.
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Published
2019-10-16
How to Cite
Lima, T. de S., Oliveira Filho, R. B. de, Sousa, M. S., Santos, N. T. A., Sampaio, R. A. G., & Lucena, R. B. (2019). Cytological, histopathological, histochemical, and immunohistochemical findings of multiple cutaneous nodules in a bovine. Semina: Ciências Agrárias, 40(6Supl3), 3781–3788. https://doi.org/10.5433/1679-0359.2019v40n6Supl3p3781
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