Kidney disease in natural infection by Ehrlichia canis in dogs
DOI:
https://doi.org/10.5433/1679-0359.2019v40n2p981Keywords:
Monocytic ehrlichiosis, Dog, Glomerulonephritis, Biomarker.Abstract
Canine monocytic ehrlichiosis, caused by the intracellular bacterium Ehrlichia canis, can affect different organs, including the kidneys, in different stages of infection, and kidney involvement is considered one of the main causes of death related to the disease. This study aimed to investigate the occurrence of kidney disease in dogs naturally infected with E. canis and to correlate antibody levels with the severity of renal disease. Serum concentrations of urea, creatinine, and proteins (albumin and globulin), along with urine concentration, urine gamma-glutamyl transferase, and urine protein levels, were evaluated in 60 dogs with E. canis infection diagnosed by polymerase chain reaction. The detection of anti-E. canis antibodies was also performed for each dog. Of the 60 dogs with E. canis infection, 73.33% presented anti-E. canis antibodies. Laboratory abnormalities consistent with renal disease were observed in 33 (55%) infected dogs, and of these, 43.3% were in stage I chronic kidney disease. A positive correlation was observed between antibody levels and total plasma protein (p = 0.0332) and serum globulin (p = 0.0057) levels. In this study, renal disease was observed on routine laboratory testing in 55% of dogs with monocytic ehrlichiosis; however, there was no correlation between the stage of renal disease and the antibody titer against E. canis.Downloads
References
BARTGES, J. W. Chronic kidney disease in dog and cats. Veterinary Clinics of North America: Small Animal Practice, Philadelphia, v. 42, n. 4, p. 669-692, 2012.
BONFANTI, U.; ZINI, E.; MINETTI, E.; ZATELLI, A. Free light-chain proteinuria and normal renal histopathology and function in 11 dogs exposed to Leishmania infantum, Ehrlichia canis, and Babesia canis. Journal of Veterinary Internal Medicine, Philadelphia, v. 18, n. 5, p. 618-624, 2004.
CASTRO, M. B.; MACHADO, R. Z.; AQUINO, L. P.; ALESSI, A. C.; COSTA, M. T. Experimental acute canine monocytic ehrlichiosis: clinicopathological and immunopathological findings. Veterinary Parasitology, Amsterdam, v. 115, n. 1, p. 73-86, 2004.
CODNER, E. C.; CACEI, T.; SAUNDERS, G. K.; SMITH, C. A.; ROBERTSON, J. L.; MARTIN, R. A.; TROY, G. C. Investigation of glomerular lesions in dogs with acute experimentally induced Ehrlichia canis infection. American Journal of Veterinary Research, Chicago, v. 53, n. 12, p. 2286-2291, 1992.
CRIVELLENTI, L. Z.; SILVA, G. E. B.; BORIN-CRIVELLENTI, S.; DANTAS, M.; ADIN, C. A.; CIANCIOLO, R.; SANTANA, A. E. Glomerulopathies in dogs with erlichiosis -preliminary results. In: CONFERENCE WORLD SMALL ANIMAL VETERINARY ASSOCIATION - WSAVA, 40th, 2015, Bangkok. Proceeding… Bangkok: WSAVA Congress, 2015. p. 76.
FREITAS, G. C.; VEADO, J. C. C.; CARREGARO, A. B. Testes de avaliação de injúria renal precoce em cães e gatos. Semina: Ciências Agrárias, Londrina, v. 35, n. 1, p. 411-426, 2014.
GOLDSTEIN, R. E.; BROVIDA, C.; FERNANDEZ-DEL PALACIO, M. J.; LITTMAN, M. P.; POLZIN, D. J.; ZATELLI, A.; COWGILL, L. D. Consensus recommendations for treatment for dogs with serology positive glomerular disease. Journal of Veterinary Internal Medicine, Philadelphia, v. 27, p. 60-66, 2013. Supplement 1.
HEIENE, R.; KRISTIANSEN, V.; TEIGE, J.; JANSEN, J. H. Renal histomorphology in dogs with pyometra and control dogs, and long term clinical outcome with respect to signs of kidney disease. Acta Veterinaria Scandinavica, London, v. 49, n. 13, p. 1-9, 2007.
INTERNATIONAL RENAL INTEREST SOCIETY - IRIS. IRIS Staging of CKC. Seattle: IRIS, 2013. Available at: http://iris-kidney.com/pdf/n378.008-iris-website-staging-of-ckd-pdf.pdf. Accessed at: 18 junho. 2017.
JAIN, N. C. Essencials of veterinary hematology. Philadelphia: Lea e Febiger, 1993. 417 p.
KANTEK, G.; NAVARRO, C. E. Manual de urinálise veterinária. São Paulo: Varela, 1996. 96 p.
MURPHY, G. L.; EWING, S. A.; WHITWORTH, L. C.; FOX, J. C.; KOCAN, A. A. Molecular and serologic survey of Ehrlichia canis, Ehrlichia chaffeensis, and E. ewingii in dogs and ticks from Oklahoma. Veterinary Parasitology, Amsterdam, v. 79, n. 4, p. 325-339, 1998.
PRESSLER, B. M. Clinical approach to advanced renal function testing in dogs and cats. The Veterinary Clinics of North America Small Animal Practice, Philadelphia, v. 43, n. 6, p. 1193-1208, 2013.
WANER, T.; HARRUS, S. Canine monocytic ehrlichiosis-from pathology to clinical manifestations. Israel Journal of Veterinary Medicine, Raanana, v. 68, n. 1, p. 12-18, 2013.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Semina: Ciências Agrárias
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Semina: Ciências Agrárias adopts the CC-BY-NC license for its publications, the copyright being held by the author, in cases of republication we recommend that authors indicate first publication in this journal.
This license allows you to copy and redistribute the material in any medium or format, remix, transform and develop the material, as long as it is not for commercial purposes. And due credit must be given to the creator.
The opinions expressed by the authors of the articles are their sole responsibility.
The magazine reserves the right to make normative, orthographic and grammatical changes to the originals in order to maintain the cultured standard of the language and the credibility of the vehicle. However, it will respect the writing style of the authors. Changes, corrections or suggestions of a conceptual nature will be sent to the authors when necessary.
