Chenopodium ambrosioides L. essential oil and ethanol extract on control of canine Ancylostoma spp.

Authors

  • Jessica Nascimento Moraes Monteiro Universidade Federal do Espírito Santo
  • Anderson Barros Archanjo Universidade Federal do Espírito Santo http://orcid.org/0000-0002-9305-271X
  • Gabriela Porfirio Passos Universidade Federal da Bahia
  • Adilson Vidal Costa Universidade Federal do Espírito Santo
  • Lenir Cardoso Porfirio Universidade Federal do Espírito Santo
  • Isabella Vilhena Freire Martins Universidade Federal do Espírito Santo

DOI:

https://doi.org/10.5433/1679-0359.2017v38n4p1947

Keywords:

Essential oil, Helminths, Herb of Santa Maria, Medicinal plants.

Abstract

The use of Chenopodium ambrosioides L. has shown to be promising in the management of gastrointestinal nematodes. The objective of this study was to quantitate the yield and characterize the chemical composition of the essential oil of C. ambrosioides, as well as to evaluate the in vitro effect of the ethanolic extract and the essential oil in L3 of Ancylostoma spp. and the in vivo effect(s) of the essential oil in dogs. The effects of the ethanol extract and essential oil on Ancylostoma spp. were evaluated in vitro by exposing larvae to the extract at concentrations ranging from 0.005 g mL-1 to 0.2 g mL-1 and to essential oil at concentrations of 50, 100, and 150 ?L mL-1. For the in vivo test, 26 healthy dogs, naturally infected by Ancylostoma spp., were divided into three groups: F1 - cookies were administered without active principle; F2 - herbal cookies containing 37.5 ?L g-1 essential oil of C. ambrosioides L.; F3 - cookies plus a commercial formulation containing febantel, pyrantel, praziquantel, and ivermectin. Complete blood counts and serum biochemistry for AST, ALT, AF, urea, creatinine, total protein, and albumin were performed. The yield of the essential oil was 0.3% m v-1, and its major components included ?-terpinene (1.24%), p-cymene (4.83%), and ascaridol Z (87%) and E (5.04%) isomers. The concentrations of C. ambrosioides L. ethanol extract used were ineffective against Ancylostoma spp. larvae. The essential oil at a concentration of 150 ?L mL-1 was effective against L3 larvae. In the in vivo study in dogs, the herbal cookies containing C. ambrosioides L essential oil reduced the number of eggs per gram of feces.

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Author Biographies

Jessica Nascimento Moraes Monteiro, Universidade Federal do Espírito Santo

Discente, Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Espírito Santo, UFES, Alegre, ES, Brasil.

Anderson Barros Archanjo, Universidade Federal do Espírito Santo

Discente, Programa de Pós-Graduação em Biotecnologia, UFES, Vitória, ES, Brasil.

Gabriela Porfirio Passos, Universidade Federal da Bahia

Discente, Programa de Pós-Graduação em Ciência Animal nos Trópicos, Universidade Federal da Bahia, UFBA, Salvador, BA, Brasil.

Adilson Vidal Costa, Universidade Federal do Espírito Santo

Prof., Departamento de Química e Física, UFES, Alegre, ES, Brasil.

Lenir Cardoso Porfirio, Universidade Federal do Espírito Santo

Prof., Departamento de Medicina Veterinária, UFES, ES, Brasil.

Isabella Vilhena Freire Martins, Universidade Federal do Espírito Santo

Profa, Departamento de Medicina Veterinária, UFES, ES, Brasil.

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Published

2017-08-04

How to Cite

Monteiro, J. N. M., Archanjo, A. B., Passos, G. P., Costa, A. V., Porfirio, L. C., & Martins, I. V. F. (2017). Chenopodium ambrosioides L. essential oil and ethanol extract on control of canine Ancylostoma spp. Semina: Ciências Agrárias, 38(4), 1947–1954. https://doi.org/10.5433/1679-0359.2017v38n4p1947

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