Effect of dietary plants on the production of immunoglobulins A in healthy Wistar rats
DOI:
https://doi.org/10.5433/1679-0367.2022v43n1p119Keywords:
Curcuma, Cinnamomum, Abelmoschus, Antibodies, Medicinal plantsAbstract
Introduction: some plants such as turmeric, cinnamon, and okra are known to have therapeutic functions such as antioxidant and anti-inflammatory activity. Furthermore, an immunomodulatory role has been observed in the production of antibodies, in particular immunoglobulin A (IgA), which mediates a variety of protective functions for the organism.
Objective: the aim of the present study was to investigate the effect of dietary plants on the production of IgA in healthy Wistar rats.
Methods: thus, 48 male Wistar rats of 90 days of age were allocated to four groups. The animals were treated for 14 days with dried turmeric, cinnamon, or okra (50, 50, 12.5 mg/day, respectively) in phosphate buffered saline, or with only phosphate buffered saline by gavage. The animals received water and feed ad libitum. Body mass and relative weight ofperitoneal fat, adrenal gland, kidney, spleen, liver and thymus, biochemical parameters, and IgA levels were analyzed.
Results: no significant changes were observed in the body mass, relative weight of organs and tissues, and biochemical parameters. An increase in serum IgA levels was observed in animals treated with turmeric or cinnamon.
Conclusion: we conclude that the treatment with turmeric and cinnamon increased IgA production. Therefore, our study supports the idea that dietary supplementation with these plants may improve humoral immunity.
Downloads
References
Al-Taee MF, Al-Ahmed HI, Malek HWA. Studying the effect of aqueous extract from Curcuma longa on some parameters of cytogenetic, immunity and fertility in female mice. Baghdad Science Journal. 2011;8(1):73-80. doi: 10.21123/bsj.8.1.73-80
Bagheri Y, Babaha F, Falak R, Yazdani R, Azizi G, Sadri M, et al. IL-10 induces TGF-β secretion, TGF-β receptor II upregulation, and IgA secretion in B cells. Eur Cytokine Netw. 2019;30(3):107-13. doi: 10.1684/ecn.2019.0434.
Deyno S, Eneyew K, Seyfe S, Tuyiringire N, Peter EL, Muluye RA, et al. Efficacy and safety of cinnamon in type 2 diabetes mellitus and pre-diabetes patients: A meta-analysis and meta-regression. Diabetes Res Clin Pract. 2019;156:107815. doi: 10.1016/j.diabres.2019.107815
Eigner D, Scholz D. Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal. J Ethnopharmacol. 1999;67(1):1-6. doi: 10.1016/s0378-8741(98)00234-7.
Fernandes EV, Ramos AC, Santos AH, Longhini R, Gerardin DCC, Venancio EJ. Effects of maternal exposure to extract of Trichilia catigua on antibody production in the offspring of Wistar rats. Nat Prod Res. 2019;33(5):763-6. doi: 10.1080/14786419.2017.1408097
Gemede HF, Ratta N, Haki GD, Woldegiorgis AZ, Beyene F. Nutritional quality and health benefits of okra (Abelmoschus esculentus): a review. J Food Process Technol. 2015;4(6):208-15. doi: 10.11648/j.ijnfs.20150402.22
Hewlings SJ, Kalman DS. Curcumin: A Review of Its' Effects on Human Health. Foods. 2017;6(10). doi: 10.3390/foods6100092
Jagetia GC, Aggarwal BB. "Spicing up" of the immune system by curcumin. J Clin Immunol. 2007;27(1):19-35. doi: 10.1007/s10875-006-9066-7
Kim SP, Lee SJ, Nam SH, Friedman M. Turmeric bioprocessed with mycelia from the shiitake culinary-medicinal mushroom Lentinus edodes (Agaricomycetes) protects mice against salmonellosis. Int J Med Mushrooms. 2017;19(4):363-76. doi: 10.1615/IntJMedMushrooms.v19.i4.70.
Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, et al. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 2017;174(11):1325-48. doi: 10.1111/bph.13621
Kwon HK, Hwang JS, Lee CG, So JS, Sahoo A, Im CR, et al. Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells. World J Gastroenterol. 2011;17(8):976-86. doi: 10.3748/wjg.v17.i8.976
Lai PK, Roy J. Antimicrobial and chemopreventive properties of herbs and spices. Curr Med Chem. 2004;11(11):1451-60. doi: 10.2174/0929867043365107
Lamuela Raventós RM. Folin–Ciocalteu method for the measurement of total phenolic content and antioxidant capacity. Measurement of Antioxidant Activity & Capacity: Recent Trends and Applications. 2018:107-17. doi: 10.1002/9781119135388.ch6
Latimer G Jr, editor. Official Methods of Analysis of AOAC International. 21st ed. Rockville: AOAC INTERNATIONAL; 2019.
Lee BJ, Kim YJ, Cho DH, Sohn NW, Kang H. Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation. Immunopharmacol Immunotoxicol. 2011;33(4):714-22. doi: 10.3109/08923973.2011.564185
Liu IM, Liou SS, Cheng JT. Mediation of beta-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2006;104(1-2):199-206. doi: 10.1016/j.jep.2005.09.001
Lobato LP, Fernandes EV, Juliani LC, Ferrari O, Ramos SP, Gerez JR, et al. The effects of oat bran and soy flour on humoral immune response in rats fed hypercholesterolaemic diets. Semina: Ciênc Biol Saúde [Internet]. 2017 [cited 2021 Nov 18];38(2):165-74. Available from: https://www.uel.br/revistas/uel/index.php/seminabio/article/view/28694/23166
Maithilikarpagaselvi N, Sridhar MG, Swaminathan RP, Sripradha R, Badhe B. Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats. Pharm Biol. 2016;54(12):2857-63. doi: 10.1080/13880209.2016.1187179
Munn EA, Feinstein A, Munro AJ. Electron microscope examination of free IgA molecules and of their complexes with antigen. Nature. 1971;231(5304):527-9. doi: 10.1038/231527a0
Ndjouenkeu R, Goycoolea FM, Morrisa ER, Akingbala JO. Rheology of okra (Hibiscus esculentus L.) and dika nut (Irvingia gabonensis) polysaccharides. Carbohydr Polym. 1996; 29 (3):263-69. doi: 10.1016/0144-8617(96)00016-1
Okazaki Y, Han Y, Kayahara M, Watanabe T, Arishige H, Kato N. Consumption of curcumin elevates fecal immunoglobulin A, an index of intestinal immune function, in rats fed a high-fat diet. J Nutr Sci Vitaminol (Tokyo). 2010;56(1):68-71. doi: 10.3177/jnsv.56.68
Pabst O, Slack E. IgA and the intestinal microbiota: the importance of being specific. Mucosal Immunol. 2020;13(1):12-21. doi:10.1038/s41385-019-0227-4
Pierce, A. The American Pharmaceutical Practical Guide to Natural Medicines. Nova Iorque: The Stonesong Press; 1999.
Sousa-Pereira P, Woof JM. IgA: Structure, Function, and Developability. Antibodies (Basel). 2019;8(4):57. doi: 10.3390/antib8040057
The Plant List: a working list of all plant species. [Internet]. 2013 [cited 2021 Nov 15]. Available from: //www.theplantlist.org/
Vangalapati M, Sree SN, Surya PDV, Sumanjali A. A review on pharmacological activities and clinical effects of cinnamon species. Res J Pharm Biol Chem Sci. 2012;3(1):653-63.
Wang K, Li M, Wen X, Chen X, He Z, Ni Y. Optimization of ultrasound-assisted extraction of okra (Abelmoschus esculentus (L.) Moench) polysaccharides based on response surface methodology and antioxidant activity. Int J Biol Macromol. 2018;114:1056-63. doi: 10.1016/j.ijbiomac.2018.03.145
Woof JM, Kerr MA. The function of immunoglobulin A in immunity. J Pathol. 2006;208(2):270-82. doi: 10.1002/path.1877.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Semina: Ciências Biológicas e da Saúde
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
adopts the CC-BY-NC license for its publications, the copyright being held by the author, in cases of republication we recommend that authors indicate first publication in this journal.
This license allows you to copy and redistribute the material in any medium or format, remix, transform and develop the material, as long as it is not for commercial purposes. And due credit must be given to the creator.
The opinions expressed by the authors of the articles are their sole responsibility.
The magazine reserves the right to make normative, orthographic and grammatical changes to the originals in order to maintain the cultured standard of the language and the credibility of the vehicle. However, it will respect the writing style of the authors. Changes, corrections or suggestions of a conceptual nature will be sent to the authors when necessary.
This Journal is licensed with a license Creative Commons Assignment-NonCommercial 4.0 International.
