Role of leptin in the pathogenesis of breast cancer

Authors

  • Thayse Fachin Cormanique Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Francielli Aparecida Garcia da Costa Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Eglea Yamamoto Della Justina Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Geise Ellen Broto Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Jessica Zardin de Moraes Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Thamara Andressa Fagundes Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Eduardo Moreira Saboia Gomes Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Erika Tomie Takakura Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Nadia Bertechini Soler Lopes Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Thiemy Nishi Loli Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Vanessa Rye Goto Universidade Estadual do Oeste do Paraná - UNIOESTE
  • Vanessa Jacob Victorino Instituto Federal do Paraná - IFPr
  • Carolina Panis Universidade Estadual do Oeste do Paraná (UNIOESTE)

DOI:

https://doi.org/10.5433/1679-0367.2015v36n2p97

Keywords:

, Leptin, Breast cancer, Obesity, Immune response.

Abstract

Leptin is a small polypeptide codified by the Obese Gene (OB), deeply related with the body fat mass and energetic balance. Due to its diverse biological effects and downstream signal transducers, multiple classifications have been attributed to leptin, as hormone, cytokine, adypokine, growth factor, and developmental factor, among others. This scenario gives us an idea of the size of the potential biological effects generated by this molecule. The concentration of leptin in the body is determined by the amount of adipose tissue; therefore, hyperleptinemia is a common finding in obese individuals. In addition, high levels of circulating leptin may confer a poor prognosis for any pathological condition. Although leptin history has been reported for more than 20 years, its relationship with cancer has gained notoriety in the past ten years, where studies focused on discussing the issue of obesity as a strong risk factor for cancer developing. Further, growing evidences have pointed leptin as a pivotal mediator of immune response, which aggravates the scenario of cancer occurrence in the presence of obesity. Therefore, leptin can present at least two faces in the pathogenesis of breast cancer, acting by immune and non-immune mechanisms. In this paper we review the dynamic of the leptin axis in breast cancer and further discuss its role in disease, immunopathogenesis and prognosis.

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Author Biographies

Thayse Fachin Cormanique, Universidade Estadual do Oeste do Paraná - UNIOESTE

Medical Student. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

Francielli Aparecida Garcia da Costa, Universidade Estadual do Oeste do Paraná - UNIOESTE

Medical Student. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

Eglea Yamamoto Della Justina, Universidade Estadual do Oeste do Paraná - UNIOESTE

Medical Student. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

Geise Ellen Broto, Universidade Estadual do Oeste do Paraná - UNIOESTE

Pharmaceutical. Master's Health Sciences program. State University of Londrina (UEL). Londrina, Paraná, Brazil.

Jessica Zardin de Moraes, Universidade Estadual do Oeste do Paraná - UNIOESTE

Graduating in Medicine. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

Thamara Andressa Fagundes, Universidade Estadual do Oeste do Paraná - UNIOESTE

Medical Student. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

Eduardo Moreira Saboia Gomes, Universidade Estadual do Oeste do Paraná - UNIOESTE

Graduating in Medicine. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

Erika Tomie Takakura, Universidade Estadual do Oeste do Paraná - UNIOESTE

Medical Student. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

Nadia Bertechini Soler Lopes, Universidade Estadual do Oeste do Paraná - UNIOESTE

Medical Student. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

Thiemy Nishi Loli, Universidade Estadual do Oeste do Paraná - UNIOESTE

Medical Student. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

Vanessa Rye Goto, Universidade Estadual do Oeste do Paraná - UNIOESTE

Medical Student. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

Vanessa Jacob Victorino, Instituto Federal do Paraná - IFPr

Biologist. Master in Experimental Pathology from Universidade Estadual de Londrina (UEL). Doctor of Sciences, Faculty of Medicine, University of São Paulo (USP). Biology discipline of teaching. Federal Institute of Paraná (IFPR). Londrina, Paraná, Brazil.

Carolina Panis, Universidade Estadual do Oeste do Paraná (UNIOESTE)

PhD in Experimental Pathology from Universidade Estadual de Londrina (UEL). Postdoctoral fellow in Oncology at the National Cancer Institute (INCA). Medical school's faculty. State University of Western Paraná (UNIOESTE). Francisco Beltrao, Paraná, Brazil.

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Published

2016-02-11

How to Cite

1.
Cormanique TF, Costa FAG da, Justina EYD, Broto GE, Moraes JZ de, Fagundes TA, et al. Role of leptin in the pathogenesis of breast cancer. Semin. Cienc. Biol. Saude [Internet]. 2016 Feb. 11 [cited 2024 Nov. 21];36(2):97-116. Available from: https://ojs.uel.br/revistas/uel/index.php/seminabio/article/view/23504

Issue

Vol. 36 No. 2 (2015)

Section

Artigos de Revisão

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