Effect of intranasal detomidine in horses undergoing odontoplasty
DOI:
https://doi.org/10.5433/1679-0359.2025v46n6p1999Keywords:
Alpha-2 adrenergic agonists, Equines, Odontoplasty, Sedation.Abstract
This study aimed to evaluate the effects of intranasal administration of detomidine at a dose of 30 μg kg-1 in horses undergoing odontoplasty. Thirteen healthy, crossbred horses were used, and the following parameters were measured: heart rate (HR), respiratory rate (f), systolic arterial pressure (SAP), rectal temperature (RT), head height relative to the ground (HH), blood glucose (BG), intestinal motility (GI motility), sedation score, and the presence of upper eyelid and lip ptosis. Measurements were taken at baseline (M0) and at 10, 30, 60, 90, and 120 min after intranasal administration. Hematocrit (Hct) and leukogram (LEU) were evaluated at M30, M60, M90, and M120. Periodontal sensitivity was assessed at M30 and during the odontoplasty procedure (upper, lower, and incisor teeth), as well as at its conclusion. Statistically significant differences (p ≤ 0.05) were observed for HR, f, RT, Hct, WBC, HH, and GI motility. No significant changes were found in SAP or BG. All animals exhibited more pronounced sedation at M90. Periodontal sensitivity was detected in 69.23% of the animals, all of which responded to dental floating of the lower incisors. Intranasal detomidine at a dose of 30 µg kg-1 promotes mild sedation in horses, with a late onset and without clinically relevant cardiovascular changes, but is insufficient to allow periodontal procedures when used alone.
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