Evaluation of cortisol and glycemia levels of dogs anesthetized with sevoflurane and premedicated with either butorphanol or phetidine

Authors

  • Ewaldo de Mattos Junior Universidade de São Paulo
  • Gustavo José von Glehn dos Santos Universidade Regional de Gurupi
  • Claudia Russo Universidade Luterana do Brasil
  • João Paulo Elsen Saut Universidade Federal de Uberlândia
  • Selwyn Arlinton Headley St. Mattew’s University

DOI:

https://doi.org/10.5433/1679-0359.2009v30n2p425

Keywords:

Anesthesia, Opioids, Neuroendocrine stress, Canine.

Abstract

The objective of this study was to compare the influence of butorphanol and phetidine as part of the preanesthetic medication, in 20 healthy dogs submitted to experimental orthopedic surgery. Dogs were randomly allocated in two groups: GI, acepromazine and butorphanol (0,05 mg.kg 1 and 0,4 mg.kg 1, respectively, i.m.) and, GII, acepromazine and phetidine (0,05 mg.kg 1and 4 mg.kg 1, respectively, i.m.). Anesthesia was induced by administration of propofol (5 mg.kg 1) and maintained by the use of sevoflurane delivered in a 100% oxygen circuit. Plasma concentrations of cortisol and glucose were measured during several surgical procedures: T0, before preanesthetic medication; T1, 20 minutes after preanesthetic medication; T2, at skin incision; T3, at periostal stimulation; and, T4, at skin suture. Concentrations of plasma glucose were not significantly different between the surgical procedures and between the two groups evaluated. Concentrations of plasma cortisol were significantly higher in dogs administered with butorphanol between the surgical procedures of T0 and T3, compared with values for dogs administered with phetidine. These results suggest that phetidine is more adequate to control plasma cortisol in dogs submitted to orthopedic surgery than anesthesia with sevoflurane.

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Author Biographies

Ewaldo de Mattos Junior, Universidade de São Paulo

Médico Veterinário, MSc, Aluno de pós-graduação do departamento de cirurgia da Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP.

Gustavo José von Glehn dos Santos, Universidade Regional de Gurupi

MV, PhD, Departamento de Cirurgia Experimental, Faculdade de Medicina, Universidade Regional de Gurupi, Gurupi, TO.

Claudia Russo, Universidade Luterana do Brasil

MV MSc, Departamento de Cirurgia, Curso de Medicina Veterinária, Universidade Luterana do Brasil, Ji-Parana, RO.

João Paulo Elsen Saut, Universidade Federal de Uberlândia

MV, PhD, Departamento de Clinica Médica, Curso de Medicina Veterinária, Universidade Federal de Uberlândia, Uberlândia, MG.

Selwyn Arlinton Headley, St. Mattew’s University

MV, PhD, School of Veterinary Medicine, St. Mattew’s University, Grand Cayman, Cayman Islands.

Published

2009-07-21

How to Cite

Mattos Junior, E. de, Santos, G. J. von G. dos, Russo, C., Saut, J. P. E., & Headley, S. A. (2009). Evaluation of cortisol and glycemia levels of dogs anesthetized with sevoflurane and premedicated with either butorphanol or phetidine. Semina: Ciências Agrárias, 30(2), 425–434. https://doi.org/10.5433/1679-0359.2009v30n2p425

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