DNA vaccines: general concerns and its applications in human and veterinary medicine

Authors

  • Flora Satiko Kano
  • Odilon Vidotto Universidade Estadual de Londrina
  • Marilda Carlos Vidotto Universidade Estadual de Londrina

DOI:

https://doi.org/10.5433/1679-0359.2007v28n4p709

Keywords:

Anaplasma marginale, DNA vaccine, Cattle, Humoral response, Cellular response.

Abstract

The vaccination with DNA is one of the most promising immunization techniques against a pathogens variety and tumors, for which the conventional methods have not been efficient. DNA vaccines are capable to induce immune humoral and cellular response, directed to lymphocytes CD4+ and CD8+, without the necessity of live microorganisms. In spite of the great potential of inducing protective immunity, the DNA vaccine not always has success. The immunity depends on several factors such as the selection of the target gene, construction of the expression vector, frequency and via of administration of the vaccine, amount of DNA, location of the antigen codified by the plasmid and age, health and species of vaccinated animals. This revision shows the development of some vaccines of DNA for diseases of interest in the veterinary and human medicine.

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Author Biographies

Flora Satiko Kano

Médica Veterinária, Dra. Pelo Programa de Pós-Graduação em Ciência Animal.

Odilon Vidotto, Universidade Estadual de Londrina

Professor Titular do Departamento de Medicina Veterinária Preventiva (DMVP), CCA, UEL.

Marilda Carlos Vidotto, Universidade Estadual de Londrina

Professora Sênior do DMVP, CCA, UEL.

Published

2007-08-30

How to Cite

Kano, F. S., Vidotto, O., & Vidotto, M. C. (2007). DNA vaccines: general concerns and its applications in human and veterinary medicine. Semina: Ciências Agrárias, 28(4), 709–726. https://doi.org/10.5433/1679-0359.2007v28n4p709

Issue

Section

Review Article

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