Macroscopic changes in the mammary glands of healthy cats after progestogen administration
DOI:
https://doi.org/10.5433/1679-0359.2023v44n3p1059Keywords:
Feline, Mammary glands, Progestins.Abstract
The administration of contraceptives in female cats leads to problems such as pyometra, fetal maceration, mammary hyperplasia, and mammary neoplasms. Among the diseases caused by contraceptives, mammary hyperplasia has only been diagnosed in felines. However, few experimental studies have shown that contraceptive administration can cause feline mammary hyperplasia. This study aimed to evaluate the effects of the administration of a single dose of contraceptives in the mammary glands of healthy cats. Twenty cat owners who had administered contraceptives to female cats were selected. Animals were divided into two groups. Contraceptives were administered to cats in the first group, and saline solution was administered to cats in the other group (control). Before drug administration, all cats were clinically examined. Anamnesis, physical examination, blood count, biochemical tests, and abdominal ultrasonography were performed. Thirty days after the administration of contraceptives, all cats were examined, and the examinations were repeated. At 30 days, no changes were observed in the blood count or ultrasound findings. However, upon physical examination, all cats that received contraceptives showed generalized enlargement of their mammary glands. Cats in the control group were clinically normal. Ninety days after the procedure, the cats underwent an ovariohysterectomy. At that time, all cats were clinically normal and mammary enlargement regressed. It was concluded that a single contraceptive application could cause macroscopic mammary changes suggestive of hyperplasia in ten cats.
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Amorim, A. R. D., Buchini, J. L. C., Marzolla, I. P., Martins, G. C. G., Gobetti, S. T. C., & Marçal, W. S. (2020). O uso irracional de medicamentos veterinários: uma análise prospectiva. Revista Brasileira de Higiene e Sanidade Animal, 14(2), 196-205. doi: 10.5935/1981-2965.20200017 DOI: https://doi.org/10.5935/1981-2965.20200017
Anticion: Acetato de medroxiprogesterona: ampola 1ml. (2021). [Bula de remédio]. Jaboticabal, SP: UCBVET. https://ucbvet.com/produto/anticion/
Araújo, L. S., Araújo, N. L. S., Alfaro, C. E. P., & Carneiro, R. S. (2014). Morte fetal em cadelas e gatas submetidas a tratamento com anticoncepcionais atendidas no Hospital Veterinário da Universidade Federal de Campina Grande. Acta Veterinaria Brasilica, 8(Supl. 2), 193-194. doi: 10.21708/avb.2014.8.0.3963 DOI: https://doi.org/10.21708/avb.2014.8.0.3963
Dyulger, G. P., Dyulger, P. G., Alikhanov, O., Sedletskaya, E. S., Latynina, E. S., Obukhova, M. E., Leontieva, I. L., Bychkov, V. S., & Baimukanov, D. A. (2020). Epidemiology, risk factors and pathomorphological features of mammary tumors in cats. Bulletin the National Academy of Sciences of the Republic of Kazakhstan, 6(388), 78-84. doi: 10.32014/2020.2518-1467.185 DOI: https://doi.org/10.32014/2020.2518-1467.185
Inibidex: Acetato de medroxiprogesterona: 50 mg (2023). [Bula de remédio]. Vespasiano, MG: Lemainjex. https://terrazoo.com.br/produto/inibidex-injetavel-10ml/
Kennedy, M. (2018). Doenças infecciosas do gato. In S. Little (Ed.), O gato (Cap 33, pp. 1454-1556). São Paulo.
Loretti, A. P., Ilha, M. R. S., Ordás, J., & Martín De Las Mulas, J. (2005). Clinical, pathological and immunohistochemical study of feline mammary fibroepithelial hyperplasia following a single injection of depot medroxyprogesterone acetate. Journal of Feline Medicine and Surgery, 7(1), 43-52. doi: 10.1016/j.jfms.2004.05.002 DOI: https://doi.org/10.1016/j.jfms.2004.05.002
Melo, E. H. M., Câmara, D. R., Notomi, M. K., Jabour, F. F., Garrido, R. A., Nogueira, A. C. J., Santos, J. C., Jr., & Souza, F. W. (2021). Effectiveness of ovariohysterectomy on feline mammary fibroepithelial hyperplasia treatment. Journal of Feline Medicine and Surgery, 23(4), 351-356. doi: 10.1177/1098612X20950551 DOI: https://doi.org/10.1177/1098612X20950551
Mol, J. A., Van Garderen, E., Rutteman, G. R., & Rijinberk, A. (1996). New insights in the molecular mechanism of progestin-induced proliferation of mammary epithelium: induction of local biosynthesis of growth hormone (GH) in the mammary glands of dogs, cats and humans. Journal of Steroid Biochemisrty and Molecular Biology, 57(1-2), 67-71. doi: 10.1016/0960-0760(95)00251-0 DOI: https://doi.org/10.1016/0960-0760(95)00251-0
Oliveira, S. N., Zahn, F. S., Dalanezi, F. M., Araujo, E. A. B., Silva, L. F. M. C., & Prestes, N. C. (2014). Hiperplasia mamária em gata após aplicação única de medroxiprogesterona: relato de caso. Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP, 12(3), 62-62.
Pereira, P. D., Carvalheira, J., & Gartner, F. (2004). Cell proliferation in feline normal, hyperplastic and neoplastic mammary tissue - an immunohistochemical study. Veterinary Journal, 168(2), 180-185. doi: 10.1016/j.tvjl.2003.10.018 DOI: https://doi.org/10.1016/j.tvjl.2003.10.018
Robinson, B., & Noakes, D. E. (2018). Reproductive physiology of the female. In D. E. Noakes, H. Pearson, T. J. Parkinson, & G. England (Ed.), Veterinary reproduction & obstetrics (Cap. 1, pp. 2-35). Amsterdam. DOI: https://doi.org/10.1016/B978-0-7020-7233-8.00001-X
Romagnoli, S. (2002). Clinical use of hormones in the control of reproduction in bitches and queens. Proceeding of the Congress of the World Small Animal Veterinary Association, São Jorge, Granada. 27.
Romagnoli, S. (2015). Progestins to control feline reproduction: historical abuse of high doses and potentially safe use of low doses. Journal of Feline Medicine and Surgery, 17(9), 743-752. doi: 10.1177/1098612X15594987 DOI: https://doi.org/10.1177/1098612X15594987
Silva, D. C. B. C. (2020). A importância da implantação de programas sociais de castração de felinos: o que os tutores e veterinários sabem a respeito da relação da reprodução desses animais com a saúde pública e o que tem sido feito? Dissertação de mestrado, Universidade Federal da Paraíba, Areia, PB, Brasil.
Silva, F. B., Lima, A. E. S., Ribeiro, L. G. R., Costa, J. M., Neto, Costa, A. C. F., Silveira, C. P. B., & Oriá, A. (2012). Uso de aglepristone no tratamento de hiperplasia fibroepitelial mamária felina. Veterinária e Zootecnia, 19(3), 399-407.
Silva, L. D. M. (2016). Controle do ciclo estral em cadelas. Revista Brasileira de Reprodução Animal, 40(4), 180-187.
Zielke, M., Carvalho, L. F., Salame, J. P., Barboza, D. V., Gaspar, L. F. J., & Sampaio, L. C. L. (2018). Avaliação do uso de fármacos em animais de companhia sem orientação profissional. Science and Animal Health, 6(1), 29-46. doi: 10.15210/sah.v6i1.13184 DOI: https://doi.org/10.15210/sah.v6i1.13184
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