The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis
DOI:
https://doi.org/10.5433/1679-0359.2019v40n6Supl2p3079Keywords:
Therapy, Antifungal medication, Surgery, Pythium insidiosum.Abstract
Cutaneous pythiosis is an important disease affecting horses raised in regions with a hot climate and water stagnation, occurring throughout all regions of Brazil. The disease progresses rapidly, and treatment for chronic lesions is challenging. The purpose of this study was to evaluate the efficacy of fluconazole after surgical excision and electrocauterization of cutaneous lesions in horses naturally infected with Pythium insidiosum. We treated 10 horses with cutaneous pythiosis, whose diagnoses were confirmed by histopathological and immunohistochemical examinations. After surgical debridement of lesion, animals received fluconazole orally for 21 days, in combination with topical treatment for the wounds. After 7 days of therapy, there was decreased serosanguineous secretion and no kunkers in the wounds in all horses. All lesions healed completely after therapy, and there were no recurrences 10 months after discharge. When associated with surgical excision, oral fluconazole therapy was an effective treatment in clinical cases of equine cutaneous pythiosis.Downloads
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References
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WORSTER, A. A.; LILLICH, J. D.; COX, J. H.; RUSH, B. R. Pythiosis with bone lesions in a pregnant mare. Journal of the American Veterinary Medical Association, Illinois, v. 216, n. 11, p. 1795-1798, 2000. DOI: 10.2460/javma.2000.216.1795
BEN-AMI, R.; LEWIS, R. E.; KONTOYIANNIS, D. P. Immunopharmacology of modern antifungals. Clinical Infectious Diseases, Oxford, v. 47, n. 2, p. 226-235, 2008. DOI: 10.1086/589290
CARDONA-ÁLVAREZ, J.; VARGAS-VILÓRIA, M.; PATARROYO-SALCEDO, J. Pythiosis cutánea en equinos tratados con acetonida de triamcinolona. Parte 1. Caracterización clínica. Revista MVZ Córdoba, Montería, v. 21, n. 3, p. 5511-5524, 2016. DOI: 10.21897/rmvz.825
CARVALHO, A. M.; GALIZA, G. J. N.; TOMA, H. S.; MUNHOZ, T. C. P.; KOMMERS, G. D. Tratamento de pitiose em égua gestante utilizando perfusão regional intravenosa com anfotericina b e dimetilsulfóxido. Revista Brasileira de Ciência Veterinária, Niterói, v. 23, n. 1, p. 28-31, 2016. DOI: 10.4322/rbcv.2016.025
CAVALHEIRO, A. S.; MABONI, G.; AZEVEDO, M. I.; ARGENTA, J. S.; PEREIRA, D. I.; SPADER, T. B.; ALVES, S. H.; SANTURIO, J. M. In vitro activity of terbinafine combined with Caspofungin and Azoles against Pythium insidiosum. Antimicroial. Agents and Chemotherapy, Washington, v. 53, n. 5, p. 2136-2138, 2009. DOI: 10.1128/AAC.01506-08
DÓRIA, R. G. S.; CANOLA, P. A.; RIBEIRO, G.; DI FILIPO, P. A.; DIAS, D. P. M.; VALADÃO, C. A. A. Hipotireoidismo iatrôgenico em equino decorrente de excesso de iodo: relato de caso. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Belo Horizonte, v. 60, n. 3, p. 521-524, 2008. DOI: 10.1590/S0102-09352008000300001
DÓRIA, R. G. S.; CARVALHO, B. C.; FREITAS, S. H.; LASKOSKI, L. M.; COLODEL, E. M.; MENDONÇA, F. S.; SILVA, M. A. G.; GRIGOLETTO, R.; NETO FANTINATO, P. Evaluation of intravenous regional perfusion with amphotericin B and dimethylsulfoxide to treat horses for pythiosis of a limb. BMC Veterinary Research, London, v. 11, n. 152, p. 152-159, 2015. DOI: 10.1186/s12917-015-0472-z
DÓRIA, R. G. S.; FREITAS, S. H.; LINARDI, R. L.; MENDONÇA, F. S.; ARRUDA, L. P.; BOABAID, F. M.; VALADÃO, C. A. Treatment of pythiosis in equine limbs using intravenous regional perfusion of amphotericin b. Veterinary Surgery, Davis, v. 41, n. 6, p. 759-765, 2012. DOI: 10.1111/j.1532-950X.2012.01019.x
DÓRIA, R. G. S.; FREITAS, S. H.; MENDONÇA, F. S.; ARRUDA, L. P.; BOABAID, F. M.; MARTINS FILHO, A.; COLODEL, E. M.; VALADÃO, C. A. A. Utilização da técnica de imuno-histoquímica para confirmar casos de pitiose cutânea equina diagnosticados por meio de caracterização clínica e avaliação histopatológica. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Belo Horizonte, v. 66, n. 1, p. 27-33, 2014. DOI: 10.1590/S0102-09352014000100005.
GROOTERS, A. M. Pythiosis and Zygomycosis. In: SELLON, D. C.; LONG, M. T. Equine infectious diseases. 2th ed. St. Louis, Missouri: Elsevier, 2014. p. 415-421.
HIGGINS, J. C.; LEITH, G. S.; PAPPAGIANS, D.; PUSTERLA, N. Treatment of Coccidiodes immitis pneumonia in two horses with fluconazole. Veterinary Record, London, v. 159, n. 11, p. 349-351, 2006. DOI: 10.1136/vr.159.11.349
JAIN, N. C. Essentials of veterinary hematology. Davis, California: John Wiley Professio, 1993. 417 p.
KANEKO, J. J.; HARVEY, J. W.; BRUSS, M. L. Clinical biochemistry of domestic animals. California: Academic, 1997. 932 p.
KREIN, S. R.; LINDSEY, J. C.; BLAZE, C. A.; WETMORE, L. A. Evaluation of risk factors, including fluconazole administration, for prolonged anesthetic recovery times in horses undergoing general anesthesia for ocular surgery: 81 cases (2006-2013). Journal of the American Veterinary Medical Association, Schaumburg, v. 244, n. 5, p. 577-581, 2014. DOI: 10.2460/javma.244.5.577
LATIMER, F. G.; COLITZ, C. M. H.; CAMPBELL, N. B.; PAPICH, M. G. Pharmacokinetics of fluconazole following intravenous and oral administration and bodyfluid concentrations of fluconazole following repeated oral dosing in horses. American Journal of Veterinary Research, Chicago, v. 62, n. 10, p. 1606-1611, 2001. DOI: 10.2460/ajvr.2001.62.1606
LUIS-LEÓN, J.; PÉREZ, R. Pythiosis: uma patologia emergente em Venezuela. Salus online, Cidade, v. 15, n. 1, p. 79-94, 2011.
MESA-ARANGO, A. C.; SCORZONI, L.; ZARAGOZA, O. It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug. Frontiers in Microbiology, Washington, v. 3, n. 1, p. 1-10, 2012. DOI: 10.3389/fmicb.2012.00286
MORAES, A. S.; SANTURIO, J. M.; TOMICH, T. R.; ABREU, U. G. P.; JULIANO, R. S.; FFERNANDES, F. A. Impactos econômicos, sociais e ambientais de tecnologias da EMBRAPA Pantanal: Pitium-Vac® - Imunoterápico contra Pitiose Equina. Corumbá: EMBRAPA, 2013. p. 37-38.
REILLY, L. K.; PALMER, J. E. Systemic candidiasis in four foals. Journal of the American Veterinary Medical Association, Illinois, v. 205, n. 3, p. 464-466, 1994.
SAMPAIO, A. J. S. A.; GOMES, R. G.; COSENZA, M. Utilização de imunoterápico no tratamento da pitiose equina. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR, Umuarama, v. 19, n. 3, p. 165-169, 2016. DOI: 10.25110/arqvet.v19i3.2016.6090
SANTOS, C. E. P.; UBIALI, D. G.; PESCADOR, C. A.; ZANETTE, R. A.; SANTURIO, J. M.; MARQUES, L. C. Epidemiological survey of equine pythiosis in the brazilian pantanal and nearby areas: result of 76 cases. Journal of Equine Veterinary Science, New York, v. 34, n. 2, p. 270-274, 2014. DOI: 10.1016/j.jevs.2013.06.003
SPINOSA, H. S.; GORNIA, S. L.; BERNARDI, M. M. Farmacologia aplicada a Medicina Veterinária. 4. ed. Rio de Janeiro: Guanabara Koogan, 2006. 897 p.
TAINTOR, J.; CROWE, C.; HANCOCK, S.; SCHUMACHER, J.; LIVESEY, L. Treatment of conidiobolomycosis with fluconazole in two pregnant mares. Journal Veterinary Internal Medicine, Greenwood Village, v. 18, n. 2, p. 363-364, 2004.
TROST, M.; GABRIEL, A.; MASUDA, E.; FIGHERA, R.; IRIGOYEN, L.; KOMMERS, G. Aspectos clínicos, morfológicos e imunoistoquimicos da pitiose gastrintestinal canina. Pesquisa Veterinária Brasileira, Seropédica, v. 29, n. 8, p. 673-679, 2009. DOI: 10.1590/S0100-736X2009000800012
WALLEN, K.; FINKEL, R.; PANAVELIL, T. Farmacologia ilustrada. 6. ed. Porto Alegre: Artmed, 2016. 645 p.
WATANABE, M. J.; ALONSO, J. M.; ALVES, A. L. G.; YAMADA, A. L. M.; BOSCO, S. M. G.; RODRIGUES, C. A.; HUSSNI, C. A. Equine pythiosis: Report of 28 cases from São Paulo State, Brazil. Semina: Ciências Agrárias, Londrina, v. 36, n. 2, p. 909-916, 2015. DOI: 10.5433/1679-0359.2015v36n2p909
WEESE, J. S.; YU, A. A. Infectious folliculitis and dermatophytosis. Veterinary Clinics of North America: Equine Practice, Fort Collins, v. 29, n. 3, p. 559-575, 2013. DOI: 10.1016/j.cveq.2013.09.004
WORSTER, A. A.; LILLICH, J. D.; COX, J. H.; RUSH, B. R. Pythiosis with bone lesions in a pregnant mare. Journal of the American Veterinary Medical Association, Illinois, v. 216, n. 11, p. 1795-1798, 2000. DOI: 10.2460/javma.2000.216.1795
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2019-09-30
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Carvalho, A. de M., Munhoz, T. C. P., Toma, H. S., Santos, J. P. V. dos, Oliveira, L. G. S. de, Boabaid, F. M., … Kommers, G. D. (2019). The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis. Semina: Ciências Agrárias, 40(6Supl2), 3079–3088. https://doi.org/10.5433/1679-0359.2019v40n6Supl2p3079
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