Ação quimioprotetora do chá verde em ratos tratados com dietilnitrosamina

Wanderlei Onofre Schmitz; Dirceu Estevão; Rubens Cecchini; Alexandre Saito; Halha Ostrensky Saridakis

doi:10.5433/1679-0367.2011v32n2p223

Green tea chemoprotection in rats treated with diethylnitrosamine

Authors

Wanderlei Onofre Schmitz Universidade Estadual de Londrina
Dirceu Estevão Universidade Estadual de Londrina
Rubens Cecchini Universidade Estadual de Londrina
Alexandre Saito Universidade Estadual de Londrina
Halha Ostrensky Saridakis Universidade Estadual de Londrina

DOI:

https://doi.org/10.5433/1679-0367.2011v32n2p223

Keywords:

Camellia sinensis, Chemoprotector, Catechins, Diethylnitrosamine.

Abstract

Green tea (Camellia sinensis) and its main components, the catechins present several biological activities such as: antioxidant and chemoprotective action against hepatotoxic agent as diethylnitrosamine (DEN), a known cytotoxic substance. This work has the objective to evaluate and understand the green tea extract (GTE) mechanisms of action as a chemoprotector agent. Therefore, tests in vivo with Wistar rats using GTE 2% (2mg/100mL) was taken orally as the only source of water for 35 days. To verify the antioxidant and chemoprotective capacity of GTE, DEN (200mg/kg) was used as a lesion agent. The results indicate that green tea if the dosage close to the ones taken by the population is not able to expressively inhibit the lesion caused for the high dose of DEN, but the results indicated a tendency to chemoprotection, suggesting to green tea may act as a prevention substance even in low dosage in presence of a classically known hepatotoxic agent.

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Author Biographies

Wanderlei Onofre Schmitz, Universidade Estadual de Londrina

Graduado em Farmácia Bioquímica (UEL); Especialista em Análises Clínicas (UEL); Especialista em Didática e Metodologia do Ensino (UNOPAR); Mestre em Patologia Experimental (UEL)

Dirceu Estevão, Universidade Estadual de Londrina

Departamento de Ciências Patológicas, Universidade Estadual de Londrina.

Rubens Cecchini, Universidade Estadual de Londrina

Departamento de Ciências Patológicas, Universidade Estadual de Londrina.

Alexandre Saito, Universidade Estadual de Londrina

Departamento de Ciências Patológicas, Universidade Estadual de Londrina.

Halha Ostrensky Saridakis, Universidade Estadual de Londrina

Departamento de Microbiologia, Universidade Estadual de Londrina

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Published

2011-12-02

How to Cite

Schmitz WO, Estevão D, Cecchini R, Saito A, Saridakis HO. Green tea chemoprotection in rats treated with diethylnitrosamine. Semin. Cienc. Biol. Saude [Internet]. 2011 Dec. 2 [cited 2024 Aug. 31];32(2):223-34. Available from: https://ojs.uel.br/revistas/uel/index.php/seminabio/article/view/6809

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Issue

Vol. 32 No. 2 (2011)

Section

Artigos

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