Green tea chemoprotection in rats treated with diethylnitrosamine
DOI:
https://doi.org/10.5433/1679-0367.2011v32n2p223Keywords:
Camellia sinensis, Chemoprotector, Catechins, Diethylnitrosamine.Abstract
Green tea (Camellia sinensis) and its main components, the catechins present several biological activities such as: antioxidant and chemoprotective action against hepatotoxic agent as diethylnitrosamine (DEN), a known cytotoxic substance. This work has the objective to evaluate and understand the green tea extract (GTE) mechanisms of action as a chemoprotector agent. Therefore, tests in vivo with Wistar rats using GTE 2% (2mg/100mL) was taken orally as the only source of water for 35 days. To verify the antioxidant and chemoprotective capacity of GTE, DEN (200mg/kg) was used as a lesion agent. The results indicate that green tea if the dosage close to the ones taken by the population is not able to expressively inhibit the lesion caused for the high dose of DEN, but the results indicated a tendency to chemoprotection, suggesting to green tea may act as a prevention substance even in low dosage in presence of a classically known hepatotoxic agent.Downloads
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