Proliferative enteropathy caused by Lawsonia intracellularis in rabbits in Southern Brazil
DOI:
https://doi.org/10.5433/1679-0359.2020v41n5supl1p2429Palabras clave:
Lagomorphs, Bacterial disease, Ileitis, Diarrhea.Resumen
Proliferative enteropathy (PE), also known as ileitis, is a disease caused by the bacterium Lawsonia intracellularis. This disease is characterized by diarrhea and ill-thrift. The aim of this study is to describe a PE outbreak in rabbits that occurred in Southern Brazil. The farm had 700 rabbits at the time the outbreak occurred. The clinical signs were severe diarrhea, dehydration, and apathy. Necropsy was performed in 33 rabbits, and the most evident macroscopic findings were thickening of the intestinal wall, intestinal loops distended by large amounts of gas, and liquid feces. Histopathological examination demonstrated a marked proliferation of enterocytes in intestinal crypts, decrease number of goblet cells, and crypts microabscesses. Silver impregnation technique (Warthin-Starry) demonstrated in intestinal crypts inside of enterocytes cytoplasm, curved vibrioid bacteria compatible with L. intracellularis. Immunohistochemical staining with anti-L. intracellularis confirmed the agent presence. PCR was performed and L. intracellularis was confirmed as the etiological agent.Métricas
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Guedes, R. M. C. (2002). Porcine proliferative enteropathy: diagnosis, immune response and pathogenesis. Doctoral thesis, University of Minnesota, Minneapolis, MN, USA.
Guedes, R. M. C. (2008). Infecção por Lawsonia intracellularis: um problema recorrente na suinocultura do Brasil. Acta Scientiae Veterinariae, 36(1), 77-80.
Horiuchi, N., Watarai, M., Kobayashi, Y., Omata, Y., & Furuoka, H. (2008). Proliferative enteropathy involving Lawsonia intracellularis infection in rabbits (Oryctlagus cuniculus). The Journal of Veterinary Medical Science, 70(4), 389-392. doi: 10.1292/jvms.70.389
Hwang, J. M., Seo, M. J., & Yeh, J. Y. (2017). Lawsonia intracellularis in the feces of wild rodents and stray cats capture around equine farms. BMC Veterinary Research, 13, 233. doi: 10.1186/s12917-017-1155-8
Jordan, D. M., Knitted, J. P., Schwartz, K. J., Roof, M. B., & Hoffman, L. J. (2004). A Lawsonia intracellularis transmission study using a pure culture inoculated seeder-pig sentinel model. Veterinary Microbiology, 104(1-2), 83-90. doi: 10.1016/j.vetmic.2004.09.004
Klein, E. C., Gebhart, C. J., & Duhamel, G. E. (1999). Fatal outbreaks of proliferative enteritis caused by Lawsonia intracellularis in young colony-raised rhesus macaques. Journal of Medical Primatology, 28(1), 11-18. doi: 10.1111/j.1600-0684.1999.tb00084.x
Mcorist, S., & Gebhart, C. J. (2012). Proliferative enteropathy. In J. J. Zimmerman, L. A. Karriker, & A. Ramirez (Eds.), Diseases of swine (pp. 811-820). Hoboken, NJ: Wiley-Blackwell.
Peixoto, P. V., França, T. N., Ribeiro, C. T., Bezerra, P. S., Jr., & Driemeier, D. (2008). Proliferative enteropathy (Lawsonia intracellularis) outbreak in rabbits in Brazil. Pesquisa Veterinária Brasileira, 28(10), 447-451. doi: 10.1590/S0100-736X2008001000001
Percy, D. H., & Barthold, S. W. (2007). Rabbit. In S. Barthold, S. M. Griffey, & D. H. Percy (Eds.), Pathology of laboratory rodents and rabbits (pp. 375-376). Oxford, UK: Blackwell Publishing.
Pusterla, N., Mapes, S., & Gebhart, C. (2012). Further investigation of exposure to Lawsonia intracellularis in wild and feral animals captured on horse properties with equine proliferative enteropathy. Veterinary Journal, 194(2), 253-255. doi: 10.1016/j.tvjl.2012.04.012
Pusterla, N., Sanchez-Migallon Guzman, D., Vanucci, F. A., Mapes, S., White, A., Difrancesco, M., & Gebhart, C. J. (2013). Transmission of Lawsonia intracellularis to weanling foals using feces from experimentally infected rabbits. Veterinary Journal, 195(2), 241-243. doi: 10.1016/j.tvjl.2012.05.028
Sampieri, F., Allen, A. L., Pusterla, N., Vanucci, F. A., Antonopoulos, A. J., Ball, K. R. & Gebhart, C. J. (2013). The rabbit as an infection model for equine proliferative enteropathy. Canadian Journal of Veterinary Research, 77(2), 110-119.
Schoeb, T. R., & Fox, J. G. (1990). Enterocecocolitis associated with intraepithelial Campylobacter-like bacteria in rabbits (Oryctolagus cuniculus). Veterinary Pathology, 27(2), 73-80. doi: 10.1177/ 030098589002700201
Vanucci, F. A., & Gebhart, C. J. (2014). Recent advances in understanding the pathogenesis of Lawsonia intracellularis infections. Veterinary Pathology, 51(2), 465-477. doi: 10.1177/0300985813520249
Boesen, H. T., Jensen, T. K., Schmidt, A. S., Jensen, B. B., Jensen, S. M. & Moller, K. (2004). The influence of diet on Lawsonia intracellularis colonization in pigs upon experimental challenge. Veterinary Microbiology, 103(1-2), 35-45. doi: 10.1016/j.vetmic.2004.06.008
Guedes, R. M. C. (2002). Porcine proliferative enteropathy: diagnosis, immune response and pathogenesis. Doctoral thesis, University of Minnesota, Minneapolis, MN, USA.
Guedes, R. M. C. (2008). Infecção por Lawsonia intracellularis: um problema recorrente na suinocultura do Brasil. Acta Scientiae Veterinariae, 36(1), 77-80.
Horiuchi, N., Watarai, M., Kobayashi, Y., Omata, Y., & Furuoka, H. (2008). Proliferative enteropathy involving Lawsonia intracellularis infection in rabbits (Oryctlagus cuniculus). The Journal of Veterinary Medical Science, 70(4), 389-392. doi: 10.1292/jvms.70.389
Hwang, J. M., Seo, M. J., & Yeh, J. Y. (2017). Lawsonia intracellularis in the feces of wild rodents and stray cats capture around equine farms. BMC Veterinary Research, 13, 233. doi: 10.1186/s12917-017-1155-8
Jordan, D. M., Knitted, J. P., Schwartz, K. J., Roof, M. B., & Hoffman, L. J. (2004). A Lawsonia intracellularis transmission study using a pure culture inoculated seeder-pig sentinel model. Veterinary Microbiology, 104(1-2), 83-90. doi: 10.1016/j.vetmic.2004.09.004
Klein, E. C., Gebhart, C. J., & Duhamel, G. E. (1999). Fatal outbreaks of proliferative enteritis caused by Lawsonia intracellularis in young colony-raised rhesus macaques. Journal of Medical Primatology, 28(1), 11-18. doi: 10.1111/j.1600-0684.1999.tb00084.x
Mcorist, S., & Gebhart, C. J. (2012). Proliferative enteropathy. In J. J. Zimmerman, L. A. Karriker, & A. Ramirez (Eds.), Diseases of swine (pp. 811-820). Hoboken, NJ: Wiley-Blackwell.
Peixoto, P. V., França, T. N., Ribeiro, C. T., Bezerra, P. S., Jr., & Driemeier, D. (2008). Proliferative enteropathy (Lawsonia intracellularis) outbreak in rabbits in Brazil. Pesquisa Veterinária Brasileira, 28(10), 447-451. doi: 10.1590/S0100-736X2008001000001
Percy, D. H., & Barthold, S. W. (2007). Rabbit. In S. Barthold, S. M. Griffey, & D. H. Percy (Eds.), Pathology of laboratory rodents and rabbits (pp. 375-376). Oxford, UK: Blackwell Publishing.
Pusterla, N., Mapes, S., & Gebhart, C. (2012). Further investigation of exposure to Lawsonia intracellularis in wild and feral animals captured on horse properties with equine proliferative enteropathy. Veterinary Journal, 194(2), 253-255. doi: 10.1016/j.tvjl.2012.04.012
Pusterla, N., Sanchez-Migallon Guzman, D., Vanucci, F. A., Mapes, S., White, A., Difrancesco, M., & Gebhart, C. J. (2013). Transmission of Lawsonia intracellularis to weanling foals using feces from experimentally infected rabbits. Veterinary Journal, 195(2), 241-243. doi: 10.1016/j.tvjl.2012.05.028
Sampieri, F., Allen, A. L., Pusterla, N., Vanucci, F. A., Antonopoulos, A. J., Ball, K. R. & Gebhart, C. J. (2013). The rabbit as an infection model for equine proliferative enteropathy. Canadian Journal of Veterinary Research, 77(2), 110-119.
Schoeb, T. R., & Fox, J. G. (1990). Enterocecocolitis associated with intraepithelial Campylobacter-like bacteria in rabbits (Oryctolagus cuniculus). Veterinary Pathology, 27(2), 73-80. doi: 10.1177/ 030098589002700201
Vanucci, F. A., & Gebhart, C. J. (2014). Recent advances in understanding the pathogenesis of Lawsonia intracellularis infections. Veterinary Pathology, 51(2), 465-477. doi: 10.1177/0300985813520249
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Publicado
2020-08-07
Cómo citar
Cecco, B. S. de, Kemper, R. T., Sousa, S. H. de, Leite-Filho, R. V., Cruz, R. A. S. da, Guedes, R. M. C., Driemeier, D., & Sonne, L. (2020). Proliferative enteropathy caused by Lawsonia intracellularis in rabbits in Southern Brazil. Semina: Ciências Agrárias, 41(5supl1), 2429–2436. https://doi.org/10.5433/1679-0359.2020v41n5supl1p2429
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