Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects
DOI:
https://doi.org/10.5433/1679-0359.2022v43n2p827Keywords:
Anesthesia, Dog, Pain, Metamizole.Abstract
Dipyrone is an effective analgesic for managing moderate or severe postoperative pain and can be used alone for mild pain or in combination with other analgesics for any type of pain. This study aimed to examine the administration of dipyrone by continuous infusion (CI) as an adjuvant analgesic in the intraoperative period for bitches undergoing elective ovariohysterectomy (OH) and its effect on these patients’ cardiorespiratory parameters. Twenty bitches underwent an elective OH procedure. The pre-anesthetic agent was a combination of acepromazine and morphine. Propofol was used to induce anesthesia, and isoflurane was used for maintenance. Subsequently, the animals were randomly allocated into two groups: the dipyrone group (DG) received a bolus dose of dipyrone (25 mg kg -1) by CI at a rate of 10 mg kg -1 h, and the control group (CG) received a bolus dose and a CI of 0.9% NaCl solution, both groups at a rate of 5 mL kg -1 h. The parametric variables were analyzed by ANOVA, followed by Tukey's test (p < 0.05). The paired t-test (p < 0.05) was used for comparison between the groups. Statistical differences were observed for heart rate, systolic, diastolic, and mean arterial pressure, respiratory rate, and blood glucose between the periods in both groups. There were differences only in the basal values of MAP between the groups; however, most values remained within the physiological range for the species. Using the drug as an adjuvant to anesthesia did not alter cardiorespiratory parameters, and it can be used as an adjuvant in analgesia during the intraoperative period of OH.Downloads
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References
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Bednarski, R. M. (2015). Dogs and cats. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 819-826). Iowa: Wiley Blackwell.
Berry, S. H. (2015). Injectable anesthetic. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 277-296). Iowa: Wiley Blackwell.
Bragg, R. F., Bennett, J. S., Cummings, A., & Quimby, J. M. (2015). Evaluation of the effects of hospital visit stress on physiologic variables in dogs. Journal of the American Veterinary Medical Association, 46(2), 212-215. doi: 10.2460/javma.246.2.212
Derry, S., Faura, C., Edwards, J., McQuay, H. J., & Moore, R. A. (2010). Single dose dipyrone for acute postoperative pain. Cochrane Database of Systematic Reviews, 8(9), 1-48. doi: 10.1002/14651858.CD0 03227.pub2.
Fantoni, D., & Martins, A. (2011). Analgesia para cirurgia geral. In D. Fantoni (Ed.), Tratamento da dor na clínica de pequenos animais (pp. 261-275). Rio de Janeiro: Elsevier.
Fox, S. M., Mellor, D. J., Firth, E. C., Hodge, H., & Lawoko, C. R. O. (1994). Changes in plasma cortisol concentrations before, during and after analgesia, anesthesia and anesthesia plus ovariohysterectomy in bitches. Research in Veterinary Science, 57(1), 110-118. doi: 10.1016/0034-5288(94)90091-4
Flôr, P. B., Yazbek, K. V. B., Ida, K. K., & Fantoni, D. T. (2013). Tramadol plus metamizole combined or not with anti-inflammatory drugs is clinically effective for moderate to severe chronic pain treatment in cancer patients. Veterinary Anaesthesia and Analgesia, 40(3), 316-327. doi: 10.1111/vaa.12023
Giorgi, M., Lebkowska-Wieruszewska, B., Lisowski, A., Owen, H., Poapolathep, A., Kim, T. W., & De Vito, V. (2018). Pharmacokinetic profiles of the active metamizole metabolites after four different routes of administration in healthy dogs. Journal of Veterinary Pharmacology and Therapeutics, 41(3), 428-436. doi: 10.1111/jvp.12484
Gorczak, R., Valandro, M. A., Martins, R., Abatti, M., Rodrigues, G. I. J., & Soares, A. V. (2016). Infusão Continua de dipirona em um cão submetido à cistotomia e nefrotomia- relato de caso. Anais do Congresso Brasileiro da Anclivepa. Goiânia, GO., Brasil, 37.
Hanson, P. D., & Maddison, J. E. (2010). Anti-inflamatórios não esteroidais e agentes condroprotetores. In J. E. Maddison, S. W. Page, & D. B. Church (Eds.), Farmacologia clínica de pequenos animais (2a ed., pp. 282-305). Rio de Janeiro: Elsevier.
Haskins, S. C. (2015). Monitoring anesthetized patients. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 86-113). Iowa: Wiley Blackwell.
Horber, F. F., Krayer, S., Miles, J., Cryer, P., Rehder, K., & Haymond, M. W. (1990). Isoflurane and whole body leucine, glucose, and fatty acid metabolism in dogs. Anesthesiology, 73(1), 82-92. doi: 10.1097/00000542-199007000-00013
Imagawa, V. H., Fantoni, D. T., Tatarunas, A. C., Mastrocinque, S., Almeida, T. F., Ferreira, F., & Posso, I. P. (2011). The use of different doses of metamizol for post-operative analgesia in dogs. Journal of Veterinary Anaesthesia, 38(4), 385-393. doi: 10.1111/j.1467-2995.2011.00617.x
International Association for the Study of Pain (2021). IASP taxonomy. Retrieved from https://www.iasp-pain.org/resources/terminology/#analgesia
Kukanich, B., & Wiese, A. J. (2015). Opioids. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 207-226). Iowa: Wiley Blackwell.
Lamont, L. A., & Mathews, K. A. (2014). Opioides, anti-inflamatórios não esteroidais e analgésicos adjuvantes. In W. J. Tranquili, J. C. Thurmon, & K. A. Grimm (Eds.), LUMB & JONES: anestesiologia e analgesia veterinária (4a ed., pp. 270-304). São Paulo: Roca.
López-Muñoz, F. J., Godínez-Chaparro, B., Huerta-Cruz, J. C., Guevara-López, U., Domínguez-Ramírez, A. M., & Cortés-Arroyo, A. R. (2008). The antinociceptive efficacy of morphine, metamizol, or their combination in na experimental rat model with different levels of inflammatory pain. Pharmacology, Biochemistry and Behavior, 91(1), 196-201. doi: 10.1016/j.pbb.2008.07.007
Massone, F. (2011). Planos anestésicos. In F. Massone (Ed.), Anestesiologia veterinária farmacologia e técnicas texto e atlas (6a ed., pp. 33-36). Rio de Janeiro: Guanabara Koogan.
Massone, F., & Nunes, N. (2011). Aparelhos, circuitos anestésicos e monitoramentos. In F. Massone (Ed.), Anestesiologia veterinária farmacologia e técnicas texto e atlas (6a ed., pp. 47-63). Rio de Janeiro: Guanabara Koogan.
McKune, C. M., Murrell, J. C., Nolan, A. M., White, K. L., & Wright, B. D. (2015). Nociception and pain. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 584-623). Iowa: Wiley Blackwell.
Morgan, J. N., & Imagawa, V. H. (2011). Analgésicos antipiréticos: dipirona e paracetamol. In D. Fantoni (Ed.), Tratamento da dor na clínica de pequenos animais (pp. 137-149). Rio de Janeiro: Elsevier.
Otero, P. E. (2005). O manejo da dor e a medicina veterinária. In P. E. Otero (Ed.), Dor avaliação e tratamento em pequenos animais (pp. 2-5). São Caetano do Sul: Iterbook.
Pawson, P., & Forsyth, S. (2010). Agentes anestésicos. In J. E. Maddison, S. W. Page, & D. B. Church (Eds.), Farmacologia clínica de pequenos animais (2a ed., pp. 83-112). Rio de Janeiro: Elsevier.
Rankin, D. C.(2015). Sedatives and tranquilizers. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 196-206). Iowa: Wiley Blackwell.
Reece, W. O. (2006). Respiração nos mamíferos. In W. O. Reece (Ed.), Dukes fisiologia dos animais domésticos (12a ed., pp. 103-134). Rio de Janeiro: Guanabara Koogan.
Schütter, A. F., Tünsmeyer, J., & Kästner, S. B. R. (2015). Influence of metamizole on 1) minimal alveolar concentration of sevoflurane in dogs and 2) on thermal and mechanical nociception in conscious dogs. Veterinary Anaesthesia and Analgesia, 43(2), 215-226. doi: 10.1111/vaa.12289
Steffey, E. P., Mama, R. K., & Brosnan, R. J. (2015). Inhalation anesthetics. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 297-331). Iowa: Wiley Blackwell.
Vale, N. (2006). Desmistificando o uso da dipirona. In I. L. Cavalcanti (Ed.), Medicina perioperatória (pp. 1107-1124). Rio de Janeiro: SAERJ.
Zanuzzo, F. S., Teixeira, F. J., Neto, Teixeira, L. R., Diniz, M. S., Souza, V. L., Thomazini, C. M., & Steagall, V. M. (2015). Analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone-meloxicam combination in bitches undergoing ovariohysterectomy. The Veterinary Journal, 205(1), 33-37. doi: 10.1016/j.tvjl.2015.05.004
Zukowski, M., & Kotfis, K. (2009). Safety of metamizole and paracetamol for acute pain treatment. Anestezjologia Intensywna Terapia, 41(3), 170-175.
Bassanezi, B. S. B., & Oliveira, A. G. O., Fº. (2006). Analgesia pós-operatória. Revista do Colégio Brasileiro de Cirurgiões, 33(2), 116-122. doi: 10.1590/S0100-69912006000200012
Bednarski, R. M. (2015). Dogs and cats. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 819-826). Iowa: Wiley Blackwell.
Berry, S. H. (2015). Injectable anesthetic. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 277-296). Iowa: Wiley Blackwell.
Bragg, R. F., Bennett, J. S., Cummings, A., & Quimby, J. M. (2015). Evaluation of the effects of hospital visit stress on physiologic variables in dogs. Journal of the American Veterinary Medical Association, 46(2), 212-215. doi: 10.2460/javma.246.2.212
Derry, S., Faura, C., Edwards, J., McQuay, H. J., & Moore, R. A. (2010). Single dose dipyrone for acute postoperative pain. Cochrane Database of Systematic Reviews, 8(9), 1-48. doi: 10.1002/14651858.CD0 03227.pub2.
Fantoni, D., & Martins, A. (2011). Analgesia para cirurgia geral. In D. Fantoni (Ed.), Tratamento da dor na clínica de pequenos animais (pp. 261-275). Rio de Janeiro: Elsevier.
Fox, S. M., Mellor, D. J., Firth, E. C., Hodge, H., & Lawoko, C. R. O. (1994). Changes in plasma cortisol concentrations before, during and after analgesia, anesthesia and anesthesia plus ovariohysterectomy in bitches. Research in Veterinary Science, 57(1), 110-118. doi: 10.1016/0034-5288(94)90091-4
Flôr, P. B., Yazbek, K. V. B., Ida, K. K., & Fantoni, D. T. (2013). Tramadol plus metamizole combined or not with anti-inflammatory drugs is clinically effective for moderate to severe chronic pain treatment in cancer patients. Veterinary Anaesthesia and Analgesia, 40(3), 316-327. doi: 10.1111/vaa.12023
Giorgi, M., Lebkowska-Wieruszewska, B., Lisowski, A., Owen, H., Poapolathep, A., Kim, T. W., & De Vito, V. (2018). Pharmacokinetic profiles of the active metamizole metabolites after four different routes of administration in healthy dogs. Journal of Veterinary Pharmacology and Therapeutics, 41(3), 428-436. doi: 10.1111/jvp.12484
Gorczak, R., Valandro, M. A., Martins, R., Abatti, M., Rodrigues, G. I. J., & Soares, A. V. (2016). Infusão Continua de dipirona em um cão submetido à cistotomia e nefrotomia- relato de caso. Anais do Congresso Brasileiro da Anclivepa. Goiânia, GO., Brasil, 37.
Hanson, P. D., & Maddison, J. E. (2010). Anti-inflamatórios não esteroidais e agentes condroprotetores. In J. E. Maddison, S. W. Page, & D. B. Church (Eds.), Farmacologia clínica de pequenos animais (2a ed., pp. 282-305). Rio de Janeiro: Elsevier.
Haskins, S. C. (2015). Monitoring anesthetized patients. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 86-113). Iowa: Wiley Blackwell.
Horber, F. F., Krayer, S., Miles, J., Cryer, P., Rehder, K., & Haymond, M. W. (1990). Isoflurane and whole body leucine, glucose, and fatty acid metabolism in dogs. Anesthesiology, 73(1), 82-92. doi: 10.1097/00000542-199007000-00013
Imagawa, V. H., Fantoni, D. T., Tatarunas, A. C., Mastrocinque, S., Almeida, T. F., Ferreira, F., & Posso, I. P. (2011). The use of different doses of metamizol for post-operative analgesia in dogs. Journal of Veterinary Anaesthesia, 38(4), 385-393. doi: 10.1111/j.1467-2995.2011.00617.x
International Association for the Study of Pain (2021). IASP taxonomy. Retrieved from https://www.iasp-pain.org/resources/terminology/#analgesia
Kukanich, B., & Wiese, A. J. (2015). Opioids. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 207-226). Iowa: Wiley Blackwell.
Lamont, L. A., & Mathews, K. A. (2014). Opioides, anti-inflamatórios não esteroidais e analgésicos adjuvantes. In W. J. Tranquili, J. C. Thurmon, & K. A. Grimm (Eds.), LUMB & JONES: anestesiologia e analgesia veterinária (4a ed., pp. 270-304). São Paulo: Roca.
López-Muñoz, F. J., Godínez-Chaparro, B., Huerta-Cruz, J. C., Guevara-López, U., Domínguez-Ramírez, A. M., & Cortés-Arroyo, A. R. (2008). The antinociceptive efficacy of morphine, metamizol, or their combination in na experimental rat model with different levels of inflammatory pain. Pharmacology, Biochemistry and Behavior, 91(1), 196-201. doi: 10.1016/j.pbb.2008.07.007
Massone, F. (2011). Planos anestésicos. In F. Massone (Ed.), Anestesiologia veterinária farmacologia e técnicas texto e atlas (6a ed., pp. 33-36). Rio de Janeiro: Guanabara Koogan.
Massone, F., & Nunes, N. (2011). Aparelhos, circuitos anestésicos e monitoramentos. In F. Massone (Ed.), Anestesiologia veterinária farmacologia e técnicas texto e atlas (6a ed., pp. 47-63). Rio de Janeiro: Guanabara Koogan.
McKune, C. M., Murrell, J. C., Nolan, A. M., White, K. L., & Wright, B. D. (2015). Nociception and pain. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 584-623). Iowa: Wiley Blackwell.
Morgan, J. N., & Imagawa, V. H. (2011). Analgésicos antipiréticos: dipirona e paracetamol. In D. Fantoni (Ed.), Tratamento da dor na clínica de pequenos animais (pp. 137-149). Rio de Janeiro: Elsevier.
Otero, P. E. (2005). O manejo da dor e a medicina veterinária. In P. E. Otero (Ed.), Dor avaliação e tratamento em pequenos animais (pp. 2-5). São Caetano do Sul: Iterbook.
Pawson, P., & Forsyth, S. (2010). Agentes anestésicos. In J. E. Maddison, S. W. Page, & D. B. Church (Eds.), Farmacologia clínica de pequenos animais (2a ed., pp. 83-112). Rio de Janeiro: Elsevier.
Rankin, D. C.(2015). Sedatives and tranquilizers. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 196-206). Iowa: Wiley Blackwell.
Reece, W. O. (2006). Respiração nos mamíferos. In W. O. Reece (Ed.), Dukes fisiologia dos animais domésticos (12a ed., pp. 103-134). Rio de Janeiro: Guanabara Koogan.
Schütter, A. F., Tünsmeyer, J., & Kästner, S. B. R. (2015). Influence of metamizole on 1) minimal alveolar concentration of sevoflurane in dogs and 2) on thermal and mechanical nociception in conscious dogs. Veterinary Anaesthesia and Analgesia, 43(2), 215-226. doi: 10.1111/vaa.12289
Steffey, E. P., Mama, R. K., & Brosnan, R. J. (2015). Inhalation anesthetics. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), LUMB & JONES’ veterinary anesthesia and analgesia (5nd ed., pp. 297-331). Iowa: Wiley Blackwell.
Vale, N. (2006). Desmistificando o uso da dipirona. In I. L. Cavalcanti (Ed.), Medicina perioperatória (pp. 1107-1124). Rio de Janeiro: SAERJ.
Zanuzzo, F. S., Teixeira, F. J., Neto, Teixeira, L. R., Diniz, M. S., Souza, V. L., Thomazini, C. M., & Steagall, V. M. (2015). Analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone-meloxicam combination in bitches undergoing ovariohysterectomy. The Veterinary Journal, 205(1), 33-37. doi: 10.1016/j.tvjl.2015.05.004
Zukowski, M., & Kotfis, K. (2009). Safety of metamizole and paracetamol for acute pain treatment. Anestezjologia Intensywna Terapia, 41(3), 170-175.
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Published
2022-02-25
How to Cite
Gorczak, R., Valandro, M. A., Pereira, B. W., Segatto, T., Beckmann, D. V., & Thiesen, R. (2022). Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects. Semina: Ciências Agrárias, 43(2), 827–840. https://doi.org/10.5433/1679-0359.2022v43n2p827
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