Hyaluronic acid: characteristics, microbial production and industrial applications

Authors

  • Nicole Caldas Pan Universidade Estadual de Londrina – Departamento de Bioquímica e Biotecnologia.
  • Josiane Alessandra Vignoli Universidade Estadual de Londrina – Departamento de Bioquímica e Biotecnologia.
  • Cristiani Baldo Universidade Estadual de Londrina – Departamento de Bioquímica e Biotecnologia.
  • Maria Antonia Pedrine Colabone Celligoi Universidade Estadual de Londrina – Departamento de Bioquímica e Biotecnologia.

DOI:

https://doi.org/10.5433/2316-5200.2013v2n4p42

Keywords:

Hyaluronic acid, Streptococcus zooepidemicus, fermentation, industrial applications

Abstract

Hyaluronic acid (HA) is a high molecular mass polysaccharide formed from disaccharide units containing D-glucuronic acid and N-acetylglucosamine. The microbial production is replacing the HA from animal tissues, and the literature has focused on increasing the yield and molecular weight of this biopolymer. Due to its hydrophilic and viscoelastic properties, HA has been extensively used in viscosupplementation of synovial fluid of patients with arthritis, tissue repair, ophthalmological surgery, and drug delivery. Likewise, HA constitutes an essential component in a wide variety of cosmetics. In this review, we present some structural properties, nutritional and physical factors of production by Streptococcus zooepidemicus and some industrial applications of this attractive biopolymer.

Downloads

Download data is not yet available.

Downloads

Additional Files

Published

2014-03-29

Issue

Vol. 2 No. 4 (2013)

Section

Artigos de Revisão Bibliográfica

License

Os trabalhos publicados passam a ser propriedade da revista BBR: Biochemistry and Biotechnology Reports, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação nesta revista.