Glutathione S-transferase M1 (GSTM-1): ethnic distribution and relation with cancer
DOI:
https://doi.org/10.5433/1679-0367.2001v22n1p3Keywords:
GSTM-1 gene, Cancer, Ethnics groups.Abstract
Interindividual differences concerning the risk of cancer development are mostly due to a genetically determined capacity of the organism, from bacteria to man, in activating and detoxifying carcinogens. Therefore, the association among specific alleles of enzymes that are able to metabolize chemical compounds and the risk of developing several cancers, is attributed to the existence of various enzymatic steps in biometabolism, which can result in the activation or detoxification of xenobiotics. A great part of detoxification genes which have already described, is related to Glutathione S- transferase (GSTs) enzyme family. GSTM-1 gene, which belongs to this family, is polimorfic in the population and occurs in about 30-50% of the individuals, depending on the ethnical group which they belong to. In several works described in literature, GSTM-1 gene has been frequently associated to a high risk of developing several types of cancer, mostly lung cancer. Such informations are extremely important in order to determine the frequency of this gene in different populations, searching for an identification of markers that indicate cancer susceptibility.
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