Effect of photobiomodulation on interleucin-10 modulation: narrative review of clinical studies
DOI:
https://doi.org/10.5433/1679-0367.2021v42n2p236Keywords:
Inflammation, Anti-Inflammatory cytokine, Immune response, Low level laser, LEDAbstract
The immune system involves several immune response mechanisms that are essential for the body to remain in balance and protected. Among these mechanisms, there is the expression of anti-inflammatory and immunomodulatory cytokines, such as interleukin-10 (IL-10). This anti-inflammatory cytokine plays a crucial role in the immune system, since it performs numerous biological functions. Studies have shown that photobiomodulation therapy (PBMT) has been effective in modulating the cytokine IL-10, increasing its expression, in various diseases of an inflammatory character. Although the mechanism of action of PBMT is not yet fully understood, it has been shown to be a promising therapy for these diseases. Therefore, the objective of this work was to review clinical studies in which they evaluated the release / expression of the cytokine IL-10 in several pathologies in response to PBMT, and to discuss the current and potential evidences of photobiomodulation.Downloads
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Avci P, Gupta A, Sadasivam M, Vecchio D, Pam Z, Pam N, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg. 2013;32(1):41-52.
Blijlevens NM, Donnelly JP, De Pauw BE. Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview. Bone Marrow Transplant. 2000 Jun;25(12):1269-78. doi: 10.1038/sj.bmt.1702447
Cox AJ, Pyne DB, Saunders PU, Callister R, Gleeson M. Cytokine responses to treadmill running in healthy and illness- prone athletes. Med Sci Sports Exerc. 2007;39(11):1918-26. doi: 10.1249/mss.0b013e318149f2aa
Derkacz A, Protasiewicz M, Poręba R, Doroszko A, Andrzejak R. Effect of the intravascular low energy laser illumination during percutaneous coronary intervention on the inflammatory process in vascular wall. Lasers Med Sci. 2013 May;28(3):763-8. doi: 10.1007/s10103-012-1142-z
Dompe C, Moncrieff L, Matys J, Grzech-Le´sniak K, Kocherova L, Bryja A, et al. Photobiomodulation-underlying mechanism and clinical applications. J Clin Med. 20203;9(6):1724. doi: 10.3390/jcm9061724
Freitas LF, Hamblin MR. Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):7000417. doi: 10.1109/JSTQE.2016.2561201
Gonçalves PF, Huang H, McAninley S, Alfant B, Harrison P, Aukhil I, et al. Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis. J Periodontol. 2013 Dec;84(12):1801-8. doi: 10.1902/jop.2013.130002
Harnish CR, Sabo RT. Comparison of two different sprint interval training work-to-rest ratios on acute inflammatory responses. Sports Med Open. 2016;2:20. doi: 10.1186/s40798-016-0044-1
Jukema JW, Verschuren JJW, Ahmed TAN, Quax PHA. Restenosis after PCI. Part 1: pathophysiology and risk factors. Nat Rev Cardiol. 2011 Sep 13;9(1):53-62. doi: 10.1038/nrcardio.2011.132
Kotenko SV. The family of IL-10-related cytokines and their receptors: related, but to what extent? Cytokine Growth Factor Rev. 2002;13(3):223-40. doi: 10.1016/s1359-6101(02)00012-6
Lins RDAU, Dantas EM, Lucena KCR, Catão MHCV, Granville-Garcia AF, Carvalho LG Neto. Efeitos bioestimulantes do laser de baixa potência no processo de reparo. An Bras Dermatol. 2010;85(6):849-55. doi:10.1590/S0365-05962010000600011
Malta ES, Lira FS, Machado FA, Zago AS, Amaral SL, Zagatto AM. Photobiomodulation by led does not alter muscle recovery indicators and presents similar outcomes to cold-water immersion and active recovery. Front Physiol. 2019;9:1948. doi: 10.3389/fphys.2018.01948
Matarese G, Ramaglia L, Cicciù M, Cordasco G, Isola G. The effects of diode laser therapy as an adjunct to scaling and root planing in the treatment of aggressive periodontitis: A 1-Year randomized controlled clinical trial. Photomed Laser Surg. 2017 Dec;35(12):702-9. doi: 10.1089/pho.2017.4288
Mosser DM, Zhang X. Interleukin-10: new perspectives on an old cytokine. Immunol Rev. 2008;226:205-18. doi: 10.1111/j.1600-065X.2008.00706.x
Mozzati M, Martinasso G, Cocero N, Pol R, Maggiora M, Muzio G, et al. Influence of superpulsed laser therapy on healing processes following tooth extraction. Photomed Laser Surg. 2011 Aug;29(8):565-71. doi: 10.1089/pho.2010.2921
Oton-Leite AF, Silva GBL, Morais MO, Silva TA, Leles CR, Valadares MC, et al. Effect of low level laser therapy on chemoradiotherapy induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients. Lasers Surg Med. 2015 Apr;47(4):296-305. doi: 10.1002/lsm.22349
Ouyang W, Rutz S, Crellin NK, Valdez PA, Hymowitz SG. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol. 2011;29:71-109. doi: 10.1146 / annurev-immunol-031210-101312
Papas AS, Clark RE, Martuscelli G, O’Loughlin KT, Johansen E, Miller KB. A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell trans- plantation. Bone Marrow Transplant. 2003 Apr;31(8):705-12. doi: 10.1038/sj.bmt.1703870
Saraiva M, O’Garra A. The regulation of IL 10 production by immune cells. Nat Ver Immunol. 2010;10(3):170-81. doi: 10.1038/nri2711
Saxena A, Khosraviani S, Noel S, Mohan D, Donner T, Hamad ARA. Interleukin-10 paradox: a potent immunoregulatory cytokine that has been difficult to harness for immunotherapy. Cytokine. 2015;74(1):27-34. doi: 10.1016/j.cyto.2014.10.031
Silva GBL, Sacono NT, Othon-Leite AF, Mendonça EF, Arantes AM, Bariani C, et al. Effect of low-level laser therapy on inflammatory mediator release during chemotherapy-induced oral mucositis: a randomized preliminary study. Lasers Med Sci. 2015;30(1):117-26. doi: 10.1007/s10103-014-1624-2
Silva T, Fragoso YD, Rodrigues MFSD, Gomes AO, Silva FC, Andreo L, et al. Effects of photobiomodulation on interleukin-10 and nitrites in individuals with relapsing-remitting multiple sclerosis – Randomized clinical trial. PLoS One. 2020 Apr;15(4):e0230551. doi: 10.1371/journal.pone.0230551
Sziksz E, Pap D, Lippai R, Béres NJ, Fekete A, Szabó AJ, et al. Fibrosis Related inflammatory mediators: role of the IL-10 cytokine family. Mediators Inflamm. 2015;2015:764641. doi: 10.1155/2015/764641
von Leden RE, Cooney SJ, Ferrara TM, Zhao Y, Dalgard CL, Anders JJ, et al. 808 nm Wavelength light induces a dose-dependent alteration in microglial polarization and resultant microglial induced neurite growth. Lasers Surg Med. 2013 Apr;45(4):253-63. doi: 10.1002/lsm.22133
Wang K, Song F, Fernandez-Escobar A, Luo G, Wang JH, Sun Y. The properties of cytokine in multiple sclerosis: pros and cons. Am J Med Sci. 2018 Dec;356(6):552-60. doi: 10.1016/j.amjms.2018.08.018
Zagatto AM, Ramos SP, Nakamura FY, Lira FS, Lopes-Martins RAB, Carvalho RLP. Effects of low-level laser therapy on performance, inflammatory markers, and muscle damage in young water polo athletes: a double-blind, randomized, placebo-controlled study. Lasers Med Sci. 2016 Apr;31(3):511-21. doi: 10.1007/s10103-016-1875-1
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Published
2021-09-28
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David AC, Zamuner SR. Effect of photobiomodulation on interleucin-10 modulation: narrative review of clinical studies. Semin. Cienc. Biol. Saude [Internet]. 2021 Sep. 28 [cited 2025 Feb. 16];42(2):236-42. Available from: https://ojs.uel.br/revistas/uel/index.php/seminabio/article/view/42614
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