Comparative study of excipients for propanolol hydrochloryde tablets prepared by means of diferent techniques
DOI:
https://doi.org/10.5433/1679-0367.2001v22n1p19Keywords:
Propranolol hydrochloride, Tablet, Wet granulation, Direct compression.Abstract
Systemic arterial hipertension (SAH) is one of the major factors in cardiovascular risk, since it contributes to the existence of more than 500 thousand cases of cerebral vascular accidents (CVA), 150 thousand deaths by cerebral hemorrhage and approximately a million myocardium infarctions (IAM). In Brazil, it is estimated that about 15% of the adult population can be considered hypertensive. Hypertension can be prevented by changes in lifestyle, although in most cases, the treatment with drugs becomes necessary. Propranolol hydrochloride is the drug chosen for the hypertensive elderly population who has had myocardium infarctation previously. The drug is commercially available as injections, solutions, capsules and tablets. Tablets can be prepared using three different techniques. The most used technique is the granulation by moisture. With the advance of new excipients available in the market for the Pharmaceutical Industry, a more simple and economical technique became possible, improving the physical and chemical stability of the product, reaching the goal of getting more efficient and safer medicine. The purpose of this study was to develop formulations of propranolol hydrochloride tablets through the variation of excipients and manufacture techniques. The propranolol hydrochloryde tablets were stored at 37o C and 50o C with 90% UR for 90 days, and analysed in pre-established time intervals the formulations were evaluated as for the physical and physical-chemical aspects.
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