Pregnancy: an immune challenge

Authors

  • Maria Angelica Ehara Watanabe Universidade Estadual de Londrina
  • Ellen Cristine Duarte-Garcia Center of Biological Sciences of Universidade Estadual de Londrina
  • Giovana Gomes de Carvalho Center of Biological Sciences of Universidade Estadual de Londrina
  • Natália Kimie Matsubara Center of Biological Sciences of Universidade Estadual de Londrina
  • Ana Camila Vaitkevicius Ferreira Center of Biological Sciences of Universidade Estadual de Londrina
  • Nágela Ghabdan Zanluqui Center of Biological Sciences of Universidade Estadual de Londrina
  • Gabriela Gonçalves de Oliveira Universidade de São Paulo

DOI:

https://doi.org/10.5433/1679-0367.2014v35n2p147

Keywords:

Pregnancy. Immunology. HLA-G. Antibodies. Cytokines.

Abstract

Several studies demonstrate the importance of immunological aspects of pregnancy. During pregnancy, the embryo is implanted in the womb, where it will develop until the end of pregnancy. Amongst the immune aspects, the importance of the modulation of T lymphocytes, natural killers (NK) cells and many cytokines in maternal organism can be mentioned. The maternal tolerance to the fetus appears to be mediated by specific maternal hormones and by the expression of human leukocyte antigen G (HLA-G) - characteristic in pregnancy. Other studies suggest that fetal rejection and complications during pregnancy may occur because of the presence of minor histocompatibility antigens (mHAg), acquired by blood sharing of the mother with the fetus, and because of the presence of maternal antibodies against the sperm and against the fetus. The purpose of this review is to describe the immunological aspects that allow maternal tolerance to the fetus during pregnancy, as well as possible causes for rejection of the embryo and complications during pregnancy.

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Author Biographies

Maria Angelica Ehara Watanabe, Universidade Estadual de Londrina

PhD in Biological Sciences (Biochemistry) from the Universidade de São Paulo, Brazil. Associate Professor, Department of Pathological Sciences, Universidade Estadual de Londrina.

Ellen Cristine Duarte-Garcia, Center of Biological Sciences of Universidade Estadual de Londrina

Graduating in Biomedicine, Center of Biological Sciences of Universidade Estadual de Londrina.

Giovana Gomes de Carvalho, Center of Biological Sciences of Universidade Estadual de Londrina

Graduating in Biomedicine, Center of Biological Sciences of Universidade Estadual de Londrina.

Natália Kimie Matsubara, Center of Biological Sciences of Universidade Estadual de Londrina

Graduating in Biomedicine, Center of Biological Sciences of Universidade Estadual de Londrina.

Ana Camila Vaitkevicius Ferreira, Center of Biological Sciences of Universidade Estadual de Londrina

Graduating in Biomedicine, Center of Biological Sciences of Universidade Estadual de Londrina.

Nágela Ghabdan Zanluqui, Center of Biological Sciences of Universidade Estadual de Londrina

Graduating in Biomedicine, Center of Biological Sciences of Universidade Estadual de Londrina.

Gabriela Gonçalves de Oliveira, Universidade de São Paulo

PhD in Experimental Pathology from Universidade Estadual de Londrina. Post doctoral student in Imunoparasitologia Laboratory, in Faculdade de Medicina de Ribeirão Preto-USP.

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Published

2014-09-21

How to Cite

1.
Watanabe MAE, Duarte-Garcia EC, Carvalho GG de, Matsubara NK, Vaitkevicius Ferreira AC, Zanluqui NG, et al. Pregnancy: an immune challenge. Semin. Cienc. Biol. Saude [Internet]. 2014 Sep. 21 [cited 2024 Dec. 17];35(2):147-62. Available from: https://ojs.uel.br/revistas/uel/index.php/seminabio/article/view/17219

Issue

Vol. 35 No. 2 (2014)

Section

Artigos de Revisão

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